Nintedanib

Description

Nintedanib is an anticancer medicine which is used to treat idiopathic pulmonary fibrosis, a progressive lung disease that causes scarring of the lungs. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Nintedanib

  • Diarrhea
  • Nausea
  • Vomiting
  • Weight loss
  • Severe stomach pain
  • Coughing up blood
  • Dizziness
  • Headache
  • Irregular heartbeat
  • Nosebleed
  • Constipation
  • Dry skin
  • Hair loss
  • Slow heart beat
  • Unusual tiredness or weakness

Uses of Nintedanib

What is it prescribed for?

  • Idiopathic pulmonary fibrosis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to nintedanib or any other inactive ingredients present along with it.

Moderate to severe liver impairment

This medicine is not recommended for use in patients with moderate to severe liver impairment due to the risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Side effects

This medicine may cause side effects such as diarrhea, nausea or vomiting in some patients on therapy. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative might be required in some cases.

Driving or Operating machinery

Use of this medicine may cause dizziness, visual disturbances, and tiredness. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

Liver impairment

This medicine should be used with extreme caution in patients with mild liver impairment due to the risk of worsening of the patient's condition. Close monitoring of liver function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases. This medicine is not recommended for use in patients with moderate to severe liver impairment.

Smoking

Smoking may alter the desired effects of Nintedanib and hence it is advised to avoid smoking while taking this medicine.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients suffering from stomach or intestine problems due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Bleeding

This medicine should be used with extreme caution in patients with a known risk of bleeding due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Heart diseases

This medicine should be used with caution in patients with heart diseases due to the increased risk of worsening of the patient's condition. Close monitoring of the heart function, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Dexamethasone

Leflunomide

Phenytoin

Carbamazepine

Aspirin

Disease interactions

Lung Toxicity

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal impairment

This medicine should be used with extreme caution in patients with mild to moderate kidney impairment due to the risk of worsening of the patient's condition. Close monitoring of kidney function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases.

Hepatic impairment

This medicine should be used with extreme caution in patients with mild liver impairment due to the risk of worsening of the patient's condition. Close monitoring of liver function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases. This medicine is not recommended for use in patients with moderate to severe liver impairment.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with food, exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Consult your doctor in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by blocking the action of certain substances that are involved in causing fibrosis and makes breathing easier
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Multikinase inhibitors

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 12 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB09079

[Internet]. Medlineplus.gov. 2018 [cited 12 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a615009.html

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 12 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Vargatef

DailyMed - OFEV- nintedanib capsule [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 13 May 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da1c9f37-779e-4682-816f-93d0faa4cfc9

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Information on this page was last updated on 13 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.