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New Zix RP Capsule
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New Zix RP Capsule

Manufactured byJENBURKT PHARMACEUTICALS LTD
ContainsAceclofenac (100 mg) + Rabeprazole (10 mg)
Description
New Zix RP Capsule is a combination of Aceclofenac and Rabeprazole. It is used to relieve pain, stiffness, and swelling associated with conditions such as osteoarthritis (wearing off of the flexible tissues at the ends of your bones), rheumatoid arthritis (pain and swelling in the small joints), ankylosing spondylitis (fusion of small bones in the spine), sprains or strain, lower back pain, etc. Aceclofenac relieves pain and Rabeprazole prevents acidity and ulceration that may be caused by the use of Aceclofenac. New Zix RP Capsule may cause some side effects like nausea, vomiting, diarrhoea, stomach pain, etc. Consult your doctor if these symptoms persist or become worse. Avoid driving vehicles or operating machines after taking this medicine as it may cause dizziness in some cases. New Zix RP Capsule may be taken with or without food. The dose and duration of treatment will be decided by your doctor based on the severity of your condition. Take this medicine at the same time daily for the ease of remembering. Do not discontinue this medicine without consulting your doctor, as it may worsen your symptoms. New Zix RP Capsule is not recommended for use if you are allergic to Aceclofenac, Rabeprazole, or any other ingredients present in this formulation. Inform your doctor if you have heart, liver, or kidney problems, NSAID-sensitive asthma (narrowing of the airways due to the use of non-steroidal anti-inflammatory medicines), or osteoporosis (a condition with weak and brittle bones) before taking this medicine. New Zix RP Capsule is not recommended for use in children below 18 years of age as the safety and efficacy data are not clinically available. Consult your doctor if you are pregnant or are breastfeeding before taking this medication.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for New Zix RP Capsule

  • Dizziness
  • Skin Rash
  • Stomach pain
  • Diarrhoea
  • Nausea and vomiting
  • Dry mouth
  • Dark urine
  • Drowsiness

Uses of New Zix RP Capsule

What is it prescribed for?

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Mild to Moderate pain
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of New Zix RP Capsule can be observed within one to three hours.
  • How long do the effects of this medicine last?
    The effect of New Zix RP Capsule lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with New Zix RP Capsule due to the increased risk of serious side effects such as severe stomach and intestinal bleeding, dizziness, fatigue, weakness, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for New Zix RP Capsule.
  • Can this medicine be taken during pregnancy?
    New Zix RP Capsule is not recommended for use in pregnancy as it may harm your foetus. Hence, consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Due to the lack of safety information, New Zix RP Capsule is not recommended for use while breastfeeding unless absolutely necessary. All the risks and benefits should be discussed with your doctor before taking this medicine.

Allergy

New Zix RP Capsule is not recommended for use if you are allergic to Aceclofenac, Rabeprazole, or any other ingredients present in this formulation. Seek immediate medical attention if you notice any symptoms such as skin rash, hives (itchy, painful eruptions that sting), itching/swelling (especially of your face/tongue/throat), severe dizziness, difficulty breathing, etc.

Gastrointestinal bleeding

Peptic ulcers are sores on the lining of your stomach and intestine that may further lead to bleeding. The symptoms are blood in stools/vomit, black coloured stool, cramps in the stomach, etc. New Zix RP Capsule is not recommended for use if you have active or a history of repetitive peptic ulcers and bleeding, as it may worsen your condition.

NSAID-induced asthma

Asthma is a condition in which your airways narrow and causes breathing difficulty. New Zix RP Capsule is not recommended for use if you have a history of asthma after taking NSAIDs (non-steroidal anti-inflammatory medicines like Paracetamol, Ibuprofen, Aspirin, etc.).

Severe Liver/Kidney Impairment

New Zix RP Capsule is not recommended for use if you have severe liver and/or kidney problems. This medicine may further damage your liver and/or kidneys and worsen your condition.
Warnings for special population

Pregnancy

New Zix RP Capsule is not recommended for use in pregnancy as it may harm your foetus. Hence, consult your doctor if you are pregnant.

Breast-feeding

Due to the lack of safety information, New Zix RP Capsule is not recommended for use while breastfeeding unless absolutely necessary. All the risks and benefits should be discussed with your doctor before taking this medicine.
General warnings

Lupus erythematosus

Systemic lupus erythematosus is a condition in which your immune system attacks your body. This can affect the skin, joints, kidneys, lungs, brain, etc. The symptoms are skin rash, joint pain, and tiredness. New Zix RP Capsule should be used with caution if you have systemic lupus erythematosus, as it may further worsen your condition.

Vitamin B12 Deficiency

New Zix RP Capsule should be used with caution due to the increased risk of Vitamin B12 deficiency. This risk is especially higher if the medicine is used for a prolonged period. Your doctor may recommend appropriate vitamin B12 supplementation or replacement with a suitable alternative based on your clinical condition.

Heart Diseases

High doses of New Zix RP Capsule should be used with caution if you have pre-existing heart conditions like heart failure (a condition in which your heart is unable to pump a sufficient amount of blood), ischaemic heart diseases (heart problems due to narrowing of the blood vessels that supply oxygen to the heart), etc. This medicine may cause fluid retention (abnormal build-up of fluid in the body) and also increase the risk of a heart attack. Consult your doctor before taking this medicine.

Use in children

New Zix RP Capsule is not recommended for use in children below 18 years of age as the safety and efficacy data are not clinically established.

Driving vehicles or operating machines

New Zix RP Capsule may cause dizziness or drowsiness in some cases. Avoid performing activities that require high mental alertness like driving vehicles or operating machines if you experience such symptoms while taking this medicine.

Hypomagnesaemia

Prolonged use of New Zix RP Capsule may increase the risk of hypomagnesaemia (low blood magnesium levels). Hence, inform your doctor if you experience any symptoms like numbness/tingling in your hands/feet, muscle cramps, seizures (fits), irregular heartbeat, etc.

Bleeding disorders

New Zix RP Capsule may prolong the blood clotting time and increase the risk of bleeding. Hence, use this medicine with caution if you have bleeding or clotting defects such as haemophilia (a condition that affects the body's ability to form a proper blood clot), vitamin K deficiency, and hypoprothrombinemia (deficiency of blood clotting substance).

Missed Dose

Take the missed dose of New Zix RP Capsule as soon as you remember. If it is time for your next scheduled dose, skip the missed dose. Do not take a double dose to make up for a missed one.

Overdose

Never take more than the prescribed dose of New Zix RP Capsule. Contact your doctor in case of an overdose for further guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with New Zix RP Capsule due to the increased risk of serious side effects such as severe stomach and intestinal bleeding, dizziness, fatigue, weakness, etc.
Interaction with Medicine

Ketoconazole

Lithium

Warfarin

Nelfinavir

Digoxin

Antihypertensives

Disease interactions

Liver Disease

New Zix RP Capsule should be used with caution if you have liver problems as it may cause further liver damage. Your doctor may suggest tests to monitor your liver function and recommend appropriate dose adjustments based on your clinical condition.

Osteoporosis

Osteoporosis is a condition in which your bones become weak and brittle. It also increases the risk of bone fractures. New Zix RP Capsule when taken in high doses for a prolonged period (a year or longer) may increase the risk of osteoporosis-related fractures. Hence, it should be used with caution if you have osteoporosis.

Gastro-Intestinal toxicity

Avoid long-term use of New Zix RP Capsule as it may cause damage to your stomach and intestine. Conditions like bleeding, ulceration (sores in the lining of the stomach and intestine), and perforation (holes that form in the walls of the stomach and intestine) can occur. If you experience symptoms like indigestion, vomit with blood, or appearance of coffee-coloured dry blood in the stools, etc., consult your doctor immediately.

Impaired kidney function

New Zix RP Capsule should be used with caution if you have mild to moderate kidney problems as this medicine may cause a decline in kidney function. Your doctor may recommend tests to monitor your kidney function and recommend appropriate dose adjustments based on your clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take New Zix RP Capsule as prescribed by your doctor. It may be taken with or without food. Do not break, chew, or crush the medicine in your mouth. Swallow as a whole with plenty of water. Follow all the instructions given on the prescription label/packing insert. Do not take in larger or smaller amounts than prescribed. Ensure that you take this medicine for the recommended duration for better results. Do not stop taking this medicine without consulting your doctor. Consult your doctor if you experience any undesirable effects that persist or worsen. Avoid consuming alcohol while taking this medicine as it may increase the risk of side effects. Keep this medicine away from the reach of children and pets. Ensure that the unused or expired medicine is disposed of properly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
New Zix RP Capsule is a combination of Aceclofenac and Rabeprazole. Aceclofenac works by reducing the formation of a chemical substance in the body that causes pain and swelling. Rabeprazole reduces the production of acid in the stomach.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Proton pump inhibitors

Schedule

Schedule H

Medicines.org.uk. 2021. Aceclofenac 100 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 23 December 2021].

https://www.medicines.org.uk/emc/product/4240/smpc#gref>

Medicines.org.uk. 2021. Rabeprazole 10mg Gastro-resistant Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 23 December 2021].

https://www.medicines.org.uk/emc/product/2842/smpc#gref>

Accessdata.fda.gov. 2021. ACIPHEX® (rabeprazole sodium) Delayed-Release Tablets, for oral use. [online] Available at: < [Accessed 23 December 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020973s035204736s005lbl.pdf>

Dailymed.nlm.nih.gov. 2021. DailyMed - CLANZA CR- aceclofenac tablet, film coated. [online] Available at: < [Accessed 23 December 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a023942-01e8-4849-aa3c-1a640ffc7fd3>

Pubchem.ncbi.nlm.nih.gov. 2021. Aceclofenac. [online] Available at: < [Accessed 23 December 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Aceclofenac>

Pubchem.ncbi.nlm.nih.gov. 2021. Rabeprazole. [online] Available at: < [Accessed 23 December 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Rabeprazole>
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Information on this page was last updated on 7 Feb 2022

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