New Triglucored Forte Tablet

Manufactured bySun Pharma Laboratories Ltd.
ContainsMetformin (500 mg) + Glibenclamide (5 mg) + Pioglitazone (15 mg)
Description

New Triglucored Forte Tablet is a combination medicine used to control high blood glucose levels in patients with type 2 diabetes. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients less than 18 years of age.

Substitutes

List of substitutes for New Triglucored Forte Tablet

Side effects

Major & minor side effects for New Triglucored Forte Tablet

  • Nausea and Vomiting
  • Heartburn
  • Abdominal fullness
  • Yellowing of skin and eyes
  • Fever or chills
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Hypoglycemia
  • Painful urination
  • Difficult and painful breathing
  • Irregular heartbeat
  • Weight gain
  • Upper respiratory tract infection
  • Headache
  • Fracture of bones

Uses of New Triglucored Forte Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 15-60 minutes of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to pioglitazone, glibenclamide, any other sulfonylureas, metformin, any other biguanides, or any other inactive ingredients present along with these medicines.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with a known history of diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type I diabetes mellitus since it is not effective in treating this condition.

Bosentan

This medicine is not recommended for use in patients taking Bosentan since the risk of severe side effects is extremely high.

Heart Failure

This medicine is not recommended for use in patients with a history of heart failure since it may worsen the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypoglycemia

This medicine may cause hypoglycemia in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver diseases

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney diseases

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Weight gain

This medicine may cause a mild to moderate weight gain in some patients.

Hemolytic anemia

This medicine may cause hemolytic anemia in some patients. This risk is especially higher in patients suffering from a G6PD deficiency. Replacement with a suitable alternative may be required in such patients based on the clinical condition.

Alcohol use

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.

Change of medications

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Use in pediatrics

This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.

Type I diabetes mellitus

This medicine is not recommended for use in patients suffering from Type I diabetes since it is not effective in treating such patients.

Edema

This medicine should be used with caution in patients with edema due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Ovulation

This medicine should be used with caution in premenopausal patients due to the increase in chances of ovulation. Adequate contraceptive measures are recommended for such patients to avoid an unplanned pregnancy.

Fractures

This medicine may increase the risk of fractures in some patients. This risk is especially higher in female patients. Close monitoring of bone health is recommended during treatment with this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Bladder cancer

Use of this medicine has been associated with an increased risk of bladder cancer. It may also worsen the condition of patients suffering from bladder cancer. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Other anti-diabetic medicines

Report the use of any other anti-diabetic medication, especially insulin to the doctor before beginning treatment with this medicine. Appropriate dose adjustments and close monitoring of blood sugar levels may be required based on the clinical condition of the patient.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases based on the clinical condition.

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Amlodipine

Atenolol

Clarithromycin

Estradiol

Gatifloxacin

Ketoconazole

Gemfibrozil

Iodinated Contrast Media

Aloe Vera

Insulin injection

Ibuprofen

Disease interactions

Heart Disease

This medicine should be administered with extreme caution in patients suffering from a disease of the heart or blood vessels due to the increased risk of serious adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Diabetic Ketoacidosis

This medicine is not recommended for use in patients suffering from diabetic ketoacidosis since the risk of adverse effects is significantly high. Replacement with a suitable alternative should be considered under your doctor's supervision.

Kidney Disease

This medicine should be administered with extreme caution in patients with a known history of renal impairment due to the increased risk of serious adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine should be used with extreme caution in patients predisposed to hypoglycemic episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the blood glucose levels.

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients suffering from hemolytic anemia or G6PD deficiency since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Bladder cancer

This medicine is not recommended for use in patients suffering from bladder cancer due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Anemia

This medicine is not recommended for use in patients suffering from anemia since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as prescribed by the doctor. You are advised to take this medicine just before meals or with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor. Consult the doctor if you experience any undesirable side effects. This medicine will show better results if you maintain a strict exercise and diet regimen.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Glibenclamide works by increasing the release of insulin from the pancreas. Pioglitazone decreases insulin resistance without causing any strain on the pancreas and reduces the production of glucose from the liver. Their combination is thus better effective than monotherapy and second-line therapy in lowering the blood glucose levels.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

FDA [Internet]. 2017 [cited 20 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021178s015lbl.pdf

DailyMed - Metformin hcl tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d98aea3-35ba-447a-b88f-a5a20b612b2f

[Internet]. Medsafe.govt.nz. 2017 [cited 16 November 2017]. Available from:

http://www.medsafe.govt.nz/profs/Datasheet/d/Daoniltab.pdf

Pioglitazone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 16 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a699016.html

[Internet]. 2017 [cited 16 November 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380169/
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