Nam Safe P (500/100 mg) Tablet

Manufactured byLincoln Pharmaceuticals Ltd.
ContainsParacetamol (500 mg) + Nimesulide (100 mg)
Description

Nam Safe P (500/100 mg) Tablet is a potent and long-acting combination medicine used in conditions such as osteoarthritis and dysmenorrhea to relieve pain. It may also be used to provide relief from mild to moderate pain associated with a headache, muscle sprains, joint pain, and dental pain. Use of this medicine is not recommended for children under the age of 12 years.

Substitutes

List of substitutes for Nam Safe P (500/100 mg) Tablet

Side effects

Major & minor side effects for Nam Safe P (500/100 mg) Tablet

  • Nausea or vomiting
  • Allergic skin reaction
  • Gastric Ulcer
  • Bloody and cloudy urine
  • Anemia
  • Fatigue
  • Stomach discomfort and cramps
  • Dizziness
  • Elevated liver enzymes
  • Blood clotting disorders
  • Stevens-Johnson Syndrome
  • Heartburn

Uses of Nam Safe P (500/100 mg) Tablet

What is it prescribed for?

  • Fever and Pain
  • Osteoarthritis
  • Primary Dysmenorrhea
  • Mild to moderate pain
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in women who are pregnant or are planning to get pregnant in the near future due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to paracetamol, nimesulide, or any other components present along with these medicines.

Analgesic Nephropathy (Kidney Disease)

This medicine is not recommended for use in patients suffering from kidney diseases associated with the excessive use of painkillers.

Liver Disease

This medicine is not recommended for use in patients suffering from liver diseases due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in women who are pregnant or are planning to get pregnant in the near future due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Overdose

This medicine is available in the market in various dosage forms. Read the label carefully before consuming this medicine to avoid overdosage. Overdose may result in liver damage. Seek emergency medical attention if an overdose of this medicine is suspected.

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Chronic Malnutrition

This medicine should be used with extreme caution in patients suffering from malnourishment due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Gastro-intestinal bleeding

This medicine may cause severe gastrointestinal bleeding and perforation after prolonged usage. These adverse events may occur with or without warning symptoms. This risk is especially higher in the elderly population and in patients with a history of gastrointestinal diseases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart disease

This medicine should be used with extreme caution in patients suffering from a disorder of the heart or heart valve due to the increased risk of worsening of the patient's condition. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in Elderly Population

This medicine should be used with caution in the elderly population due to the increased risk of severe adverse effects. Appropriate dose adjustments may be required based on the clinical condition.

Kidney disease

This medicine is not recommended for use in patients suffering from kidney disease or kidney function impairment due to the increased risk of severe adverse effects. This risk is especially higher with prolonged use. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in pediatrics

This medicine is not recommended for use in children under the age of 12 years.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc.
Interaction with Medicine

Carbamazepine

Ketoconazole

Methotrexate

Phenytoin

Warfarin

Sodium Nitrite

Leflunomide

Prilocaine

Amoxicillin and Clavulanic Acid

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Report any symptoms such as nausea, fever, rashes, dark urine, etc. to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

You may get a false-positive result for this test while taking this medicine. It is advised that you inform the doctor and lab technician about all your current medicines including herbs and supplements before undergoing any lab tests.
Take this medicine exactly as prescribed by your doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Paracetamol increases the pain threshold and decreases swelling. It also brings down elevated body temperature by acting on heat regulatory centers in the brain. Nimesulide blocks the action of certain natural substances that are responsible for causing pain and inflammation.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Analgesic combinations, Analgesic antipyretic combinations

Schedule

Schedule H

European Medicines Agency - Nimesulide [Internet]. Ema.europa.eu. 2017 [cited 28 February 2017]. Available from:

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/referrals/Nimesulide/human_referral_000275.jsp&mid=WC0b01ac0580024e9a

[Internet]. 2017 [cited 14 September 2017]. Available from:

http://www.panacea-biotec.com/product-pdf/nimu1.pdf

[Internet]. 2017 [cited 23 June 2017]. Available from:

https://davisplus.fadavis.com/3976/meddeck/pdf/acetaminophen.pdf
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