Naloxegol

Description

Naloxegol belongs to the class of opioid antagonists. It is used in the treatment of constipation which is caused by opioid medicines. Patients with a history of intestinal obstruction should consult the doctor before taking this medicine.

Side effects

Major & minor side effects for Naloxegol

  • Abdominal and stomach pain
  • Diarrhea
  • Irritability
  • Sweating
  • Anxiety
  • Bloating
  • Passing gas
  • Headache
  • Nausea and Vomiting

Uses of Naloxegol

What is it prescribed for?

  • Constipation
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its effects is approximately 24 hours.
  • Duration of effect
    The time until which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. If the medicine is used, close monitoring of the infant for any adverse side effects is necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to naloxegol or any other medicines of the same class.

Bowel obstruction

Naloxegol is not recommended for use in patients with a known history of gastrointestinal obstruction or suspected gastrointestinal obstruction due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. If the medicine is used, close monitoring of the infant for any adverse side effects is necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Gastrointestinal side effects

This medicine should be used with caution due to an increased risk of side effects such as abdominal pain, diarrhea, and bloating. Report any such symptoms to the doctor immediately. Your doctor may prescribe an alternative medicine based on your clinical condition.

Missed Dose

If a dose of Naloxegol is missed, take the missed dose as soon as you remember it. If it is almost time for the next scheduled dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clarithromycin

Fluconazole

Nelfinavir

Ciprofloxacin

Disease interactions

Disease

Information not available.
Food interactions
It is recommended that you do not consume grapefruit juice while taking Naloxegol due to an increased risk of elevated blood Naloxegol levels. This may cause side effects such as sweating, runny nose, diarrhea, or abdominal pain. Report any such symptoms to the doctor on priority.
Lab interactions
Information not available.
Take Naloxegol exactly as instructed by the doctor. Do not take larger amounts than prescribed. Seek emergency medical treatment in case of any side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Naloxegol works by minimizing the effect of opioid medicines in the bowel and stomach, which helps to reduce constipation.
Legal Status

Unknown

Approved

Unknown

Unknown

Classification

Category

Peripheral opioid receptor antagonists

Schedule

N/A

Naloxegol - DrugBank [Internet]. Drugbank.ca. 2017 [cited 8 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB09049

Naloxegol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a615016.html

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 8 August 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

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Information on this page was last updated on 8 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.