Nalidixic acid

Description

Nalidixic acid is a quinolone antibiotic used to treat urinary tract infections caused by gram-negative microorganisms, including E. coli, Proteus species, Enterobacter species, and Klebsiella species. This medicine should only be used if there is a proven or strongly suspected bacterial infection.

Side effects

Major & minor side effects for Nalidixic acid

  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Double vision
  • Muscle pain
  • Confusion
  • Dizziness
  • Abdominal pain
  • Swelling of face, lips, eyelids, tongue, hands and feet

Uses of Nalidixic acid

What is it prescribed for?

  • Urinary Tract Infection
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use if you have a known allergy to nalidixic acid or any other related compounds.

Seizure Disorder

This medicine is not recommended for use in patients with a seizure disorder due to an increase in the risk of worsening of the patient's condition.

Porphyria

This medicine is not recommended for use in patients with a known history of porphyria (a disorder that result from the accumulation of porphyrins in the body) due to an increase in the risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

QT prolongation

This medicine should be used with extreme caution in patients with a history of QT prolongation due to the increased risk of worsening of the patient's condition. This risk is especially higher in patients with heart diseases or electrolyte disturbances and elderly patients. Report any incidence of discomfort in the chest, heart palpitations, etc., to the doctor on priority. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Driving or Operating machinery

Use of this medicine has been associated with symptoms such as dizziness, weakness, lightheadedness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Other uses

Your doctor may prescribe this medicine for indications other than those stated above in certain specific circumstances, especially if other medicines are not effective. All the risks and benefits should be discussed with the doctor in such cases.

Multivitamins with minerals

Intake of Nalidixic acid and multivitamins with minerals at the same time may reduce the desired effects of Nalidixic acid. Your doctor may suggest maintaining a time gap between administration of these medicines for the best possible effects.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Clostridium difficile-associated diarrhea

Discontinue the use of this medicine as per the doctor's instructions if severe diarrhea occurs after receiving this medicine. This medicine may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhea.

G6PD deficiency

This medicine should be used with extreme caution in patients with G6PD deficiency due to the risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative might be required in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Corticosteroids

Clozapine

Ethinyl Estradiol

Warfarin

Disease interactions

Central nervous system disorders

This medicine should be used with extreme caution in patients with a history of seizure disorder and other central nervous system abnormalities since it may worsen the patient's condition. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Myasthenia Gravis

This medicine is not recommended for use in patients with a known history or family history of myasthenia gravis (weakness and rapid fatigue of muscles under voluntary control) due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Tendonitis or tendon rupture

This medicine is not recommended for use in patients with a history of tendon rupture or tendinitis (a condition in which the tissue connecting muscle to the bones becomes inflamed) since it may worsen the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Diabetes

This medicine may alter the blood glucose levels and hence should be used with caution in patients with diabetes, since it may worsen the patient's condition. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Peripheral Neuropathy

This medicine should be used with caution in patients with peripheral neuropathy, since it may worsen the patient's condition. Report any side effects such as pain, burning, tingling, numbness, weakness, pain on light touch, vibratory sensation etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Consumption of food or beverages containing caffeine is not recommended during treatment with this medicine due to the risk of side effects such as severe headache, confusion, tremor, restlessness, nervousness, increased blood pressure etc.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not consume in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by inhibiting an enzyme required for the bacterial DNA to replicate, thus inhibiting bacterial cell division.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antibiotics, Quinolones Urinary anti-infectives

Schedule

Schedule H

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 19 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/nalidixic_acid

[Internet]. Drugbank.ca. 2018 [cited 19 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00779

[Internet]. Accessdata.fda.gov. 2018 [cited 19 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017430s032lbl.pdf

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Information on this page was last updated on 5 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.