Modafinil

Description

Modafinil is used to promote wakefulness in patients with extreme sleepiness during daytime or sleepiness due to sleeping disorders. It also helps in staying awake during work hours if the work schedule is not adjusted to having a scheduled sleeping time. It will not cure the sleep disorders or get rid of all kind of sleepiness. It should not be used to hold off sleep in those who do not have any sleeping disorders.

Side effects

Major & minor side effects for Modafinil

  • Hypersensitivity
  • Headache
  • Nausea
  • Fever and chills
  • Confusion
  • Trouble sleeping
  • Unusual bleeding or bruising
  • Chest pain
  • Black or Tarry stools
  • Difficulty in passing urine

Uses of Modafinil

What is it prescribed for?

  • Narcolepsy
  • Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
  • Shift work sleep disorder
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is 20 to 60 minutes.
  • Duration of effect
    This medicine remains active in the body for an average duration of 5 to 10 hours after administration.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    Modafinil may be habit forming.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired effects is necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to modafinil or its related compounds or any other components present with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired effects is necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Severe hepatic impairment

The dose should be reduced to half of the normal dose in patients with severe hepatic impairment. A normal dose may cause severe side effects in such patients.

Dizziness

This medicine may not completely cure the sleepiness caused by your disorder. This may cause drowsiness or dizziness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery during treatment with this medicine.

Consumption of alcohol

Do not consume alcohol during treatment with Modafinil due to the increased risk of drowsiness, dizziness, and impaired judgment.

Grapefruit or grapefruit juice

Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine since the combination may decrease the effects of Modafinil.

Sports

It is advised that you do not indulge in sports during treatment with this medicine. Sportspersons should refer to the list published by World Anti-Doping Agency (WADA) for medicines which should not be taken while participating in specific sports events.

Missed Dose

If a dose of Modafinil is missed, take the missed dose as soon as you remember it. If it is almost time for the next dose, continue with the normal dosing schedule. Do not double your dose to make up for the forgotten dose. It is advised that you do not take this medicine if it is too late in a waking day since you may find it difficult to sleep at night.

Overdose

Seek emergency medical treatment or contact a doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clopidogrel

Deflazacort

Ranolazine

Fentanyl

Bosutinib

Disease interactions

Cardiovascular disease

Use of Modafinil in patients with cardiac diseases like heart failure, severe hypertension, or heart rhythm disorders is contraindicated due to the increased risk of stroke, heart attack, or sudden loss of consciousness. It is advised to discuss with the doctor about all your medical conditions and current medicines before using this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.

Hypertension

Use of CNS stimulants like Modafinil in patients with severe hypertension is contraindicated due to an increased risk of cardiovascular complications such as heart attack or arrhythmias. It is advised to discuss with the doctor all the potential risks and benefits before using this medicine. Regular monitoring of blood pressure is necessary during treatment with this medicine.

Liver Disease

Use of this medicine in patients with moderate to severe liver disease is not recommended due to the increased risk of severe adverse effects. This risk is especially higher in the elderly population. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Seizure disorders

This medicine should be used with caution in patients with seizure disorders due to the increased risk of worsening of the patient's condition. If a seizure episode occurs, contact the doctor immediately and discontinue the medicine under your doctor's supervision. Your doctor may prescribe an alternative medicine based on your clinical condition.

Psychiatric disorders

This medicine should be used with caution in patients with psychiatric disorders due to the increased risk of suicidal thinking, behavioral changes, and thought changes. The patients should be monitored closely for the emergence or worsening of the psychiatric symptoms. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Strictly follow all the instructions on the label and take Modafinil only as directed. Do not take more than what is prescribed or share this medication with other people. It is advised that you should inform the doctor about all the medicines or herbal products that you are using and about all your medical conditions before taking this medicine. Do not use this medicine in place of getting a good sleep and follow all the doctor's instructions on good sleeping habits.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken in morning only

May cause sleepiness

How it works
Modafinil works by acting on the area of the brain that controls sleep and wakefulness by increasing the amounts of certain natural substances required for being awake.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Wakefullness promoting agents, Psychoanaleptic

Schedule

N/A

Modafinil: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 1 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a602016.html

[Internet]. 2017 [cited 1 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/27040

Modafinil (substance) [Internet]. Snomedbrowser.com. 2017 [cited 1 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/387004007

DBGET Search Result: All databases modafinil [Internet]. Genome.jp. 2017 [cited 1 August 2017]. Available from:

http://www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&dbkey=all&keywords=modafinil

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Information on this page was last updated on 8 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.