Milrinone

Description

Milrinone is used for the short term management of congestive heart failure. It is also used to improve heart function in patients after a heart operation. This medicine is not recommended for use if you are known allergic to it.

Side effects

Major & minor side effects for Milrinone

  • Chest pain or discomfort
  • Dizziness
  • Headache
  • Low blood pressure
  • Difficulty in breathing
  • Wheezing
  • Skin Rash

Uses of Milrinone

What is it prescribed for?

  • Congestive Heart Failure
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 5 to 15 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 3 to 5 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to milrinone, amrinone, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Kidney impairment

This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypotension

This medicine may lower the blood pressure severely in some patients. Close monitoring of the blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Electrolyte abnormalities

This medicine may imbalance the electrolytes levels and therefore should be used with caution in patients with electrolyte abnormalities due to the increased risk of adverse effects. Close monitoring of electrolytes levels is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Myocardial infarction

This medicine should be used with extreme caution in patients with a recent MI (Myocardial infarction) due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent monitoring of the cardiac functions while receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Heart valve disease

This medicine should be used with extreme caution in patients with heart valve disease due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of a missed dose is very less.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Disopyramide

Rasagiline

Tizanidine

Disease interactions

Arrhythmias

This medicine should be used with extreme caution in patients with arrhythmias due to the increased risk of worsening of the patient's condition. Regular monitoring of the ECG is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stimulating the muscles of the heart, resulting in improved blood flow.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Inotropic agents, Phosphodiesterase inhibitor

Schedule

Schedule H

Milrinone - DrugBank [Internet]. Drugbank.ca. 2019 [cited 1 April 2019]. Available from:

https://www.drugbank.ca/drugs/DB00235

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 6 October 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2013-PI-02524-1&d=201809201016933

DailyMed - Milrinone Lactate - milrinone lactate injection [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 6 October 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fa8c2d27-bb10-4966-bd8e-193fd921ea17

[Internet]. Medicines.org.uk. 2018 [cited 6 October 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.2625.pdf

[Internet]. Products.sanofi.in. 2019 [cited 1 April 2019]. Available from:

http://products.sanofi.in/Primacor.pdf

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Information on this page was last updated on 1 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.