Midodrine

Description

Midodrine is used for the treatment of orthostatic hypotension, a condition of low blood pressure that occurs when standing up quickly from sitting or lying position.

Side effects

Major & minor side effects for Midodrine

  • Headache
  • Pounding in ears
  • Blurred vision
  • Skin Rash
  • Back pain
  • Dry skin
  • Dizziness and Drowsiness
  • Nausea and vomiting

Uses of Midodrine

What is it prescribed for?

  • Orthostatic Hypotension
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 45 to 90 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 2 to 3 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to midodrine or any other inactive ingredients present along with it.

Severe organic heart disease

This medicine is not recommended for use in patients suffering from severe heart diseases like congestive heart failure, heart attack, conduction disorders, etc. due to the increased risk of worsening of the patient's condition.

Thyrotoxicosis

This medicine is not recommended for use in patients suffering from thyrotoxicosis, a condition where there is an excess of thyroid hormones in the body which may increase the risk of worsening of patient's condition.

Urinary retention

This medicine is not recommended for use in patients who are suffering from urinary retention, a condition where the patient is unable to empty the bladder, due to the increased risk of worsening of the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of severe adverse effects. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Vision problems

This medicine should be used with caution in patients with vision disorders due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving and operating machinery

Use of this medicine may cause symptoms such as dizziness, blurred vision, light-headedness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney diseases due to increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Ergotamine

Formoterol

Phenylephrine

Beta blockers

Linezolid

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. It is recommended to take this medicine during the daytime and the last daily dose should be taken before an evening meal and at least 4 hours before bedtime. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by tightening the blood vessels which in turn helps to increase the blood pressure.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous cardiovascular agents

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 6 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00211

[Internet]. Medlineplus.gov. 2018 [cited 6 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a616030.html

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 6 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=aec0d2de-ce83-b7c2-5d10-740607d50521&type=display

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 6 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/midodrine

[Internet]. Accessdata.fda.gov. 2018 [cited 6 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019815s010lbl.pdf

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Information on this page was last updated on 16 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.