Midazolam

Description

Midazolam is used before medical procedures to cause drowsiness, relieve anxiety and prevent any memory of the event. It may also be used in the short-term treatment of insomnia and emergency treatment of seizures in some cases. This medicine should be used with caution in patients with a known history of pulmonary disorders due to the increased risk of worsening of the patient's condition.

Side effects

Major & minor side effects for Midazolam

  • Anxiety
  • Chest pain and discomfort
  • Confusion
  • Drowsiness
  • Irregular heart beat
  • Irritability
  • Nausea and Vomiting
  • Nervousness
  • Shortness of breath
  • Rash

Uses of Midazolam

What is it prescribed for?

  • Light Sedation
  • Light Anesthesia
  • Insomnia
  • Seizures
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Concerns

Commonly asked questions

  • Onset of action
    The time required for this medicine to show its action is about 10 to 20 minutes by the intramuscular, intranasal, and oral administration and about 3 to 5 minutes by intravenous administration.
  • Duration of effect
    This medicine remains active in the body for about 2 to 6 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    This medicine may become habit forming in some cases. Close monitoring of the patient for any changes in behavior or mood is recommended during treatment with this medicine.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to midazolam or any other ingredients present along with it.

Acute narrow-angle glaucoma

This medicine is not recommended for use in patients with a known history of acute narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Respiratory distress

This medicine should be used with caution in patients with a known history of lung diseases due to the increased risk of worsening of the patient's condition.

Use in shock/coma/depressed respiration

This medicine should not be used in patients suffering from shock, coma, or depressed respiration due to the increased risk of worsening of the patient's condition.

Paradoxical reactions

This medicine should be used with caution due to the increased risk of paradoxical reactions. These may include excitability, nervousness, hostility, nightmares, sleep disturbances, etc. This risk is especially higher in patients with psychiatric disorders. Close monitoring of the patient for any changes in mood and behavior is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Impaired kidney and liver function

This medicine should be used with caution in patients with impaired kidney and/or liver function due to the increased risk of severe side effects.

Myasthenis gravis

Midazolam should be used with caution in patients with myasthenia gravis due to the increased risk of worsening of the patient's condition.

Missed Dose

Tablets: If the tablets are used for insomnia, take the missed dose as soon as you remember. It is advisable to skip the missed dose if it is already daytime. Try not to miss any dose as the quantity and timings are very specific and non-adherence could cause some side effects. Injection/Syrup/Nasal spray/Tablets: Since this medicine is given by a qualified healthcare professional either in emergency situations or preoperatively, the likelihood of missing a dose is very low.

Overdose

Tablets used for insomnia: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection/Syrup/Nasal Spray/Tablets: Since this medicine is administered either in emergency situations or preoperatively by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose of this medicine is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Clozapine

Fluconazole

Atazanavir

Darunavir

Disease interactions

Acute Alcohol Intoxication

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as drowsiness, dizziness, lightheadedness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol while taking Midazolam.

Respiratory Depression

This medicine should be used with extreme caution in patients with a known history of respiratory depression due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Closed-Angle Glaucoma

This medicine is not recommended for use in patients with a known history of closed-angle glaucoma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition.

Congestive heart failure

This medicine should be used with caution in patients with a known history of congestive heart failure due to the increased risk of worsening of the patient's condition. Any unusual symptoms should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Depression

This medicine should be used with caution in patients with a known history of depression due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any change in behavior or mood. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Obesity

This medicine should be used with caution in obese patients due to the increased risk of severe side effects. Any unusual symptoms should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of serious and life-threatening reactions.
Lab interactions
Information not available.
Tablets: Take Midazolam as instructed by the doctor. Your dose is likely to be changed by the doctor during the course of treatment and hence all changes should be properly followed. Do not consume this medicine in larger or smaller quantities than prescribed. You are likely to experience some side effects whenever there is a change in dose quantity or timings. The usage should be stopped gradually over time as instructed. Injection/Syrup/Nasal Spray: This medicine is usually administered by a qualified healthcare professional. Follow all the instructions given by your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Causes sleepiness

How it works
Midazolam minimizes the activity in the brain and induces relaxation, drowsiness, and sleep.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Benzodiazepines

Schedule

Schedule H1

[Internet]. 2017 [cited 31 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/1692

DailyMed - Midazolam hydrochloride injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 31 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=737361a0-8db1-4d3c-ba5e-44df3f49fa22

Midazolam - DrugBank [Internet]. Drugbank.ca. 2017 [cited 31 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00683

Midazolam: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 31 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a609003.html

[Internet]. 2017 [cited 1 September 2017]. Available from:

http://medsafe.govt.nz/profs/Datasheet/h/Hypnoveltab.pdf

[Internet]. 2017 [cited 1 September 2017]. Available from:

http://www.meppo.com/pdf/drugs/567-DORMICUM-TABLETS-1322057181.pdf

MIDACIP Nasal Spray [Internet]. CiplaMed. 2017 [cited 1 September 2017]. Available from:

https://ciplamed.com/content/midacip-nasal-spray

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Information on this page was last updated on 4 Sep 2017

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.