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Metoz L (2.5/50 mg) Tablet
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Metoz L (2.5/50 mg) Tablet

Manufactured byCentaur Pharmaceuticals Pvt. Ltd.
ContainsMetolazone (2.5 mg) + Losartan (50 mg)
Description
Metoz L (2.5/50 mg) Tablet is a combination medicine used for the treatment of high blood pressure. Frequent monitoring of blood pressure and electrolytes level is necessary during treatment with this medicine. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Metoz L (2.5/50 mg) Tablet

  • Headache
  • Dizziness
  • Abdominal pain
  • Asthenia
  • Increase in liver enzyme levels
  • Increase in serum creatinine
  • Swelling of face and lips
  • Chest pain
  • Dry mouth
  • Diarrhea
  • Increased urination
  • Increased heart beat
  • Weakness

Uses of Metoz L (2.5/50 mg) Tablet

What is it prescribed for?

  • Moderate to severe hypertension
  • Hypertension with left ventricular hypertrophy
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is about 1 hour.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on the clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to metolazone, losartan, or any other angiotensin receptor blockers.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

Severe liver impairment

This medicine is not recommended for use in patients with a known history of severe liver impairment due to the increased risk of hepatic coma and pre-coma. It is not recommended for use in patients with hepatic coma or pre-coma due to the increased risk of worsening of the patient's condition.

Aliskiren

Coadministration of aliskiren and this combination medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on the clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Volume and electrolyte imbalance

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal diseases

This medicine may cause Azotemia in patients with a known history of severe renal diseases. Close monitoring of kidney function is necessary while taking this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Hypotension

Symptomatic hypotension may occur in patients with volume depletion or patients who are treated with high-dose diuretics. It is advised to correct this condition before initiating treatment with this combination medicine.

Hyperkalemia

This medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Hepatic impairment

This medicine should be used with extreme caution in patients with liver impairment due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition.

Pediatric population

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Dexamethasone

Aliskiren

Captopril

Insulin

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Congestive heart failure

This medicine should be used with extreme caution in patients with congestive heart failure due to the increased risk of renal impairment and worsening of the patient's condition. Close monitoring of heart function, blood pressure, and kidney function is recommended for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Angioedema

This medicine is not recommended for use in patients with a history of angioedema or a family history of angioedema due to the increased risk of recurrent symptoms. Report any incidence of swelling of the face, lips, and eyes to the doctor on priority. Replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
It is advised to avoid potassium containing foods and supplements while taking this medicine due to the increased risk of weakness, confusion, irregular heartbeat, etc. Report any unusual symptoms to the doctor immediately. Your dietitian/doctor may suggest appropriate changes in your diet based on your clinical condition.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Metolazone increases the excretion of water and sodium through the urine. Losartan relaxes the blood vessels and promotes the smooth flow of blood. Their combination is thus effective in reducing blood pressure and the strain on the heart.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Thiazide diuretics, Angiotensin receptor blockers, Angiotensin II inhibitors with thiazides, Antihypertensive combinations

Schedule

Schedule H

[Internet]. 2017 [cited 26 September 2017]. Available from:

http://www.centaurpharma.com/pdf/Prescribing-Metoz-L.pdf

DailyMed - Metolazone tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 3 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b619826-2567-49d7-8972-b6da5e4467df

Metolazone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 3 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682345.html

DailyMed - Losartan potassium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 8 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cdcf8cc-4964-4c53-e054-00144ff88e88

Losartan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a695008.html
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Information on this page was last updated on 27 Oct 2017

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