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Metoclop 5 mg Injection

Manufactured byInd-Swift Laboratories Ltd.
Description
Metoclop 5 mg Injection is one of the effective anti-sickness medicine used to treat and prevent nausea and vomiting caused by cancer medicines (chemotherapy), surgery, and aid in some medical examinations involving the stomach or intestines. It is also used to treat heartburn caused by acid reflux disease when other medicines do not work well enough. In diabetic patients who have gastroparesis (poor emptying of the stomach), Metoclop 5 mg Injection is used to relieve symptoms of nausea, vomiting, and stomach discomfort/fullness by making a fast stomach emptying. Common side effects of Metoclop 5 mg Injection are diarrhoea, sleepiness, and dizziness. Do not use this medicine in people with muscle movement problems/disorders and who are previously allergic to it. Avoid use in patients with stomach or intestinal problems such as blockage, bleeding, or perforation. Metoclop 5 mg Injection is administered into a muscle or a vein by a trained healthcare professional.

Side effects

Major & minor side effects for Metoclop 5 mg Injection

  • Dizziness and Drowsiness
  • Stomach pain
  • Muscle pain and weakness
  • Headache
  • Skin rash
  • Irregular heartbeat
  • Diarrhoea
  • Restlessness
  • Lack or loss of strength
  • Difficulty in breathing
  • Pain at the injection site

Uses of Metoclop 5 mg Injection

What is it prescribed for?

  • Chemotherapy induced nausea and vomiting
  • Gastroparesis
  • Small Intestine Intubation
  • Radiological examination
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The onset of action for the metoclopramide injection can be observed within 1 to 3 minutes for injection into a vein and 10 to 15 minutes for injection into a muscle.
  • How long do the effects of this medicine last?
    The effect of a metoclopramide injection lasts for a duration of 1 to 2 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol with Metoclop 5 mg Injection is not recommended due to the risk of central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills. Do not drive a vehicle or operate heavy machinery if alcohol and Metoclop 5 mg Injection are used together.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Metoclop 5 mg Injection.
  • Can this medicine be taken during pregnancy?
    Metoclop 5 mg Injection is not recommended for use in the first and third trimesters of pregnancy unless directed by the doctor. After delivery, mothers are at moderately high risk for depression. Treatment should be avoided in women with a history of depression. If you are using Metoclop 5 mg Injection any changes in your mood or any movement disorders should be reported to the doctor immediately.
  • Can this medicine be taken while breast-feeding?
    Metoclop 5 mg Injection can pass into breast milk. Hence use is generally not recommended in breastfeeding women. If used, the baby should be observed for symptoms such as stomach discomfort and gas.

Allergy

Avoid using Metoclop 5 mg Injection if you are previously allergic to it. Allergic reactions to this medicine are rare. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Gastrointestinal disorders

Metoclop 5 mg Injection is a gastrointestinal motility agent that helps in improving the motility of the oesophagus (food pipe) and stomach. Therefore it is not recommended for use in patients with stomach or intestinal problems such as blockage, bleeding, or perforation where stimulation of gastrointestinal motility might be harmful.

Seizure disorder

A seizure is a sudden abnormal electrical disturbance in the brain. Metoclop 5 mg Injection is not recommended for use in patients with seizures due to the risk of worsening the condition.

Pheochromocytoma

Pheochromocytoma is a tumour that grows in an adrenal gland located on top of the kidneys. This tumour produces hormones like norepinephrine (noradrenaline) and epinephrine (adrenaline) which may cause high blood pressure, headache, sweating and symptoms of a panic attack. Metoclop 5 mg Injection is not recommended for use in patients with pheochromocytoma due to an increase in the risk of hypertensive crisis (very severe increase in the blood pressure).
Warnings for special population

Pregnancy

Metoclop 5 mg Injection is not recommended for use in the first and third trimesters of pregnancy unless directed by the doctor. After delivery, mothers are at moderately high risk for depression. Treatment should be avoided in women with a history of depression. If you are using Metoclop 5 mg Injection any changes in your mood or any movement disorders should be reported to the doctor immediately.

Breast-feeding

Metoclop 5 mg Injection can pass into breast milk. Hence use is generally not recommended in breastfeeding women. If used, the baby should be observed for symptoms such as stomach discomfort and gas.
General warnings

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a condition characterized by fever, muscle rigidity, involuntary movements and altered mental status. Use Metoclop 5 mg Injection cautiously in patients with a history of NMS, since NMS may recur. Do not use this medicine in patients with active NMS and should be immediately stopped if currently being used in such patients.

Depression

Depression is a common condition nowadays which can occur due to various reasons. Use Metoclop 5 mg Injection cautiously in patients with or without a prior history of depression since it may worsen the condition. If the patient has negative thoughts such as suicidal attempts, sad mood, or less social interaction, discontinue the medicine and seek medical treatment.

Kidney impairment

Kidney helps in the clearance of Metoclop 5 mg Injection from the body. Therefore, patients with impaired kidney function may require a dosage adjustment to prevent medicine accumulation in the body.

Hypertension

Metoclop 5 mg Injection can increase blood pressure and hence use it cautiously in patients with high blood pressure. Monitor blood pressure levels at regular intervals while on treatment with this medicine.

Muscle spasms

Metoclop 5 mg Injection may cause muscle spasms in the face, neck, body, arms, and legs during the first two days of use. These effects are more likely to occur in children and adults below 30 years of age.

Missed Dose

Since Metoclop 5 mg Injection is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since Metoclop 5 mg Injection is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol with Metoclop 5 mg Injection is not recommended due to the risk of central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills. Do not drive a vehicle or operate heavy machinery if alcohol and Metoclop 5 mg Injection are used together.
Interaction with Medicine

Phenytoin

Olanzapine

Chlorpromazine

Promethazine

Disease interactions

Tardive Dyskinesia

Tardive dyskinesia (TD) is a condition of involuntary and abnormal movements of your face and body. You might blink your eyes, repetitively chew, stick out your tongue, or move arms, legs or trunk without your control. Long term treatment with Metoclop 5 mg Injection should be avoided in patients with TD unless if the benefit is thought to outweigh the risk of developing TD.

Parkinsonism

Parkinsonism is a progressive condition with gradual brain tissue damage that results in the weakening of the muscle tissues, difficulty in walking and coordination. Metoclop 5 mg Injection should be used with caution in patients with parkinsonism due to the risk of worsening of parkinsonian-like symptoms such as tremors, pill-rolling motion, and postural abnormalities.
Food interactions
Information not available.
Lab interactions
Information not available.
Metoclop 5 mg Injection should be administered by a qualified healthcare professional in the clinical or hospital setting. Metoclopramide injection price may vary based on its strengths.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Metoclop 5 mg Injection works by increasing the movement of food in the stomach and the intestine. It also works by blocking a natural substance in the brain that causes nausea and vomiting.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Gastrointestinal Stimulants, Antiemetics

Schedule

Schedule H

Drugbank.ca. 2021. Metoclopramide | Drugbank Online. [online] Available at: < [Accessed 20 January 2021].

https://www.drugbank.ca/drugs/DB01233>

Dailymed.nlm.nih.gov. 2021. DailyMed - METOCLOPRAMIDE- metoclopramide hydrochloride injection. [online] Available at: < [Accessed 17 March 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=50a3cf38-66dc-4fa5-8a45-adf959c987ab>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 17 March 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/017862s063lbl.pdf>

Medicines.org.uk. 2021. Metoclopramide 5 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 17 March 2021].

https://www.medicines.org.uk/emc/product/6283/smpc#gref>

Pubchem.ncbi.nlm.nih.gov. 2021. Metoclopramide. [online] Available at: < [Accessed 20 January 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Metoclopramide>
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Information on this page was last updated on 17 Mar 2021

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