Methylphenidate

Description

Methylphenidate is used to treat symptoms of attention deficit hyperactive disorder (ADHD) in children and adults. It may improve focus and decrease impulsive and hyperactive behavior. It may also be used to treat a sleep disorder called narcolepsy. This medicine has high abuse potential and hence, therapy should be a part of the treatment program that also includes counseling and support.

Side effects

Major & minor side effects for Methylphenidate

  • Nervousness
  • Difficulty in falling or staying asleep
  • Dizziness and Drowsiness
  • Nausea and Vomiting
  • Loss of appetite
  • Stomach pain
  • Diarrhea
  • Heartburn
  • Uncontrolled muscle movements
  • Burning, numbness, tingling in the arms and feet
  • Fast/irregular heart beat
  • Chest pain
  • Shortness of breath
  • Excessive tiredness
  • Slurred speech
  • Seizures
  • Blurred vision
  • Hallucinations
  • Frequent, painful erections
  • Hives and redness of skin
  • Blistering and peeling of skin
  • Swelling of the face, lips, or tongue
  • Blood in urine and stools
  • Unusual bleeding or bruising

Uses of Methylphenidate

What is it prescribed for?

  • Attention-deficit hyperactive disorder (ADHD)
  • Narcolepsy
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is subject to vary based on the type of dosage form. The time required for the immediate release formulations to show their effect is 2 hours; for sustained-release formulations, it is 4-7 hours; and for extended-release formulations, it is 1-2 hours.
  • Duration of effect
    The effect of this medicine lasts for 3-12 hours based on the type of formulation. While the effects of a conventional tablet last for 3-6 hours, modified release tablets exert their effects for 3-12 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of severe adverse effects. Contact your doctor if you experience symptoms like drowsiness, anxiety, depression, seizures, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is it habit forming?
    This medicine has a high potential for abuse which may lead to severe psychological or physical dependence.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. Your doctor will determine the best course of treatment after evaluating the benefits and risks associated with the use of this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to methylphenidate or any other inactive ingredients present in the formulation.

Agitation

This medicine is not recommended for use in patients with marked anxiety, tension, and agitation due to the increased risk of worsening of the patient’s condition.

Glaucoma

This medicine is not recommended for use in patients with glaucoma due to the increased risk of worsening of the patient’s condition.

Tourette's Syndrome

This medicine is not recommended for use in patients with motor tics or in patients with a family history of diagnosis of Tourette's syndrome due to the increased risk of worsening of the patient’s condition.

Monoamine oxidase inhibitors (MAO)

This medicine is not recommended for use in patients undergoing treatment with monoamine oxidase inhibitors (MAOIs) such as selegiline, moclobemide etc. There should be a time gap of at least 14 days between stopping treatment with MAOIs and beginning treatment with this medicine to avoid their interaction.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. Your doctor will determine the best course of treatment after evaluating the benefits and risks associated with the use of this medicine.
General warnings

Other medicines

Methylphenidate may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Use in the elderly

This medicine is not recommended for use in patients aged above 65 since the risk of adverse events is significantly high.

Use in children

This medicine is not recommended for use in children below 6 years of age since the safety and efficacy of use are not clinically established.

Heart diseases

This medicine should be used with extreme caution in patients with active heart diseases or patients with a history of heart diseases since the risk of adverse effects or worsening of the patient's condition is significantly high. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Psychiatric disorders

This medicine should be used with caution in patients with an active psychiatric disorder or patients with a history of psychiatric disorders, especially in children and adolescents. Use should be discontinued if new symptoms appear or old symptoms are worsened.

Seizure disorders

This medicine should be used with caution in patients with an active seizure disorder or patients with a history of seizure disorders since the risk of worsening of the patient's condition is significantly high. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Growth suppression

Use of this medicine may slow growth in children. It is advised to regularly monitor your child's height and weight while this medicine is being taken. Use should be discontinued if the child is not gaining height or weight.

Digestive tract disorders

This medicine should be used with extreme caution in patients with obstructive disorders of the digestive tract. Use should be discontinued if symptoms worsen. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Abuse and dependence

This medicine has a high potential for abuse and dependence and hence should be used with extreme caution in patients with a history of drug or substance abuse.

Surgeries

Report the use of this medicine to the doctor prior to surgery. Use of this medicine should be stopped a day before the planned surgery since it may interact with the anesthetics given, causing a sudden rise in the blood pressure levels.

Driving or Operating machinery

Use of this medicine may cause blurred vision, dizziness, drowsiness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped. Do not take a double dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of severe adverse effects. Contact your doctor if you experience symptoms like drowsiness, anxiety, depression, seizures, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Amitriptyline

Tramadol

Pimozide

Selegiline

Formoterol

Epinephrine

Phenylephrine

Methylene blue

Bupropion

Clonidine

Linezolid

Salbutamol

Disease interactions

Cardiovascular disorders

This medicine should be used with extreme caution in patients with cardiovascular disorders such as uncompensated heart failure, severe coronary artery disease, severe hypertension, arrhythmias, etc. It is advised to assess the heart function of patients before treatment with this medicine is initiated. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypertension

This medicine should be used with caution in patients suffering from high blood pressure levels due to the increased risk of worsening of the patient’s condition. Regular monitoring of blood pressure levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients suffering from seizures or patients predisposed to seizures due to the increased risk of worsening of the patient’s condition. Use should be terminated if seizures are experienced. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Substance abuse

This medicine should be used with extreme caution in patients with a history of alcohol or substance abuse. The potential for habituation and abuse is significantly high with this medicine. Appropriate corrective measures, patient and caregiver education, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Low blood cell count

This medicine should be used with caution in patients with preexisting blood cell deficiencies or bone marrow suppression. Periodic monitoring of blood cell component levels is advised while this medicine is being taken by the patient. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than prescribed. Do not change the initial formulation prescribed without consulting your doctor. Report any adverse effects experienced to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine works by altering the levels of certain chemicals in the brain.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

CNS stimulants

Schedule

Schedule H

[Internet]. Fda.gov. 2018 [cited 31 August 2018]. Available from:

https://www.fda.gov/downloads/Drugs/DrugSafety/ucm089090.pdf

[Internet]. Medicines.org.uk. 2018 [cited 31 August 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.1035.pdf

DailyMed - Methylphenidate capsule, extended release [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 31 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1f8983ce-71b8-4c62-830d-e4692ddededa

Methylphenidate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 31 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/methylphenidate#section=Top

W. Alexander Morton G. Methylphenidate Abuse and Psychiatric Side Effects [Internet]. PubMed Central (PMC). 2018 [cited 31 August 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181133/

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 8 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.