Methylergometrine

Description

Methylergometrine is used for the prevention and control of excessive bleeding after a vaginal delivery. It is not recommended for use unless there is a definite need.

Side effects

Major & minor side effects for Methylergometrine

  • Headache and dizziness
  • Stomach pain
  • Chest pain
  • Increase in blood pressure
  • Change in skin color
  • Nausea and vomiting
  • Skin rash
  • Sweating
  • Difficulty in breathing

Uses of Methylergometrine

What is it prescribed for?

  • Postpartum bleeding
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Concerns

Commonly asked questions

  • Onset of action
    Oral form: The amount of time required for this medicine to show its action is not clinically established. Parenteral form: The effect of this medicine can be observed immediately after the administration of the dose.
  • Duration of effect
    Oral form: The effect of this medicine lasts up to 3 hours after an oral administration. Parenteral form: The effects of this medicine last up to 3 hours after an intramuscular administration and 45 minutes after an intravenous administration.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Hypertension

This medicine is not recommended for use in patients with hypertension (high blood pressure) due to the increased risk of worsening of the patient's condition.

Allergy

This medicine is not recommended for use if you have a known allergy to methylergometrine or any other inactive ingredients present in the formulation.

Preeclampsia

This medicine is not recommended for use in patients with a condition called preeclampsia which is characterized by high blood pressure, presence of excess protein albumin in the urine, and swelling of hands, feet, and face.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
General warnings

Use in children

This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.

Cardiovascular diseases

This medicine is not recommended for use in patients with a known history of coronary heart disease, peripheral vascular, or hypertension due to the increased risk of worsening of the patient's condition.

Missed Dose

Tablet: Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose. Injection: Since this medicine is usually administered by a qualified health care professional in a clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Tablet: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is usually administered by a qualified health care professional in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ergotamine

Bromocriptine

Sumatriptan

Verapamil

Clarithromycin

Ketoconazole

Disease interactions

Kidney impairment

This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Report any unusual symptoms to the doctor on priority. Close monitoring of the kidney function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver impairment due to the increased risk of adverse effects. Report any unusual symptoms to the doctor on priority. Close monitoring of the liver function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit and grapefruit juice is not recommended during treatment with this medicine due to the increased risk of side effects.
Lab interactions
Information not available.
Tablet: Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Injection: This medicine should be administered only by trained obstetrical personnel in a hospital setting with appropriate obstetrical care facilities. Detect whether the patient is allergic to this medicine before initiating the treatment.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine acts on the smooth muscle of the uterus to improve the muscle tone as well as strength and timing of uterine contractions that help to control bleeding.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Uterotonic agents, Ergot Derivatives

Schedule

Schedule H

Methylergonovine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 3 September 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/8226

DailyMed - Methylergonovine Maleate- methylergonovine maleate injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 3 September 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4c5f70e-da62-4d1d-a3e0-6fe5e45bb65b

Methylergometrine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00353

DailyMed - Methylergonovine Maleate- methylergonovine tablet [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 3 September 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a7ec8dfe-9b58-4363-a709-c1b72ee67855

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Information on this page was last updated on 3 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.