Methdilazine

Description

Methdilazine is a long-acting anti-allergic medicine used to relieve the symptoms caused by allergic reactions such as hay fever or urticaria (hives). These symptoms may include sneezing, runny nose, itchy eyes, skin rashes, redness of the eyes, etc. It is also used for the symptomatic relief of skin disorders with chronic itching.

Side effects

Major & minor side effects for Methdilazine

  • Dry mouth
  • Constipation
  • Drowsiness
  • Blurred vision
  • Headache
  • Fast or slow heartbeat
  • Giddiness
  • Nausea and vomiting
  • Weight gain
  • Loss of appetite
  • Nervousness

Uses of Methdilazine

What is it prescribed for?

  • Allergic rhinitis
  • Urticaria
  • Pruritic skin disorders
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 15 to 60 minutes of administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 to 12 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine. Any symptoms such as dizziness, difficulty in concentration, etc. should be reported to the doctor. If you experience any of these symptoms, you are advised to avoid activities such as driving a vehicle or operating heavy machinery.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to methdilazine or any other inactive ingredients present along with it.

Narrow-angle glaucoma

This medicine is not recommended for use in patients suffering from narrow-angle glaucoma due to the increased risk of worsening of the condition.

Asthma

This medicine is not recommended for use in patients suffering from asthma due to the increased risk of worsening of the condition.

Bone marrow depression

This medicine is not recommended for use in patients suffering from bone marrow depression due to the increased risk of worsening of the condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.
General warnings

Drowsiness and Sleepiness

This medicine usually causes symptoms such as dizziness, drowsiness, sleepiness, etc. This risk is especially higher if the patient is receiving other sedative medicines or if the patient consumes alcohol during treatment with this medicine. If you experience any of these symptoms, you are advised to avoid activities such as driving a vehicle or operating heavy machinery.

Use in pediatrics

This medicine is not recommended for use in children less than 2 years of age since the safety and efficacy of use are not clinically established.

Cardiovascular diseases

This medicine should be used with caution in patients suffering from cardiovascular diseases due to the increased risk of worsening of the condition. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Peptic ulcer

This medicine should be used with caution in patients suffering from peptic ulcers due to the increased risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Prostatic hypertrophy

This medicine should be used with caution in patients suffering from prostatic hypertrophy due to the increased risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Epilepsy

This medicine should be used with caution in children suffering from epilepsy due to the increased risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Urinary retention

This medicine should be used with caution in patients, especially children, suffering from urinary retention due to the increased risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine. Any symptoms such as dizziness, difficulty in concentration, etc. should be reported to the doctor. If you experience any of these symptoms, you are advised to avoid activities such as driving a vehicle or operating heavy machinery.
Interaction with Medicine

Betahistine

Hydrocodone

Chlorpheniramine

Disease interactions

Liver Disease

This medicine should be used with caution in patients with a history of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal Disease

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions

Urine chorionic gonadotrophin measurement

Report the use of this medicine before undergoing urine chorionic gonadotrophin measurement. This medicine may interfere with the results of this test and may give false-negative or false-positive results based on immunological reactions between human chorionic gonadotropin (HCG) and anti-HCG.
Follow all the usage instructions mentioned on the label or package insert and take/administer this medicine exactly as directed. Do not take/administer larger or smaller quantities than prescribed. Report any unusual symptoms to the doctor immediately. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine works by reducing the concentration of certain chemical substances in the body (histamines) which are responsible for causing allergic reactions.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antihistamines, Anti-allergic agent, Phenothiazine

Schedule

Schedule H

Methdilazine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/methdilazine

Methdilazine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00902

[Internet]. Toxnet.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5192

[Internet]. India-pharma.gsk.com. 2018 [cited 14 September 2018]. Available from:

https://india-pharma.gsk.com/media/701126/dilosyn-syrup-and-dilosyn-tablets.pdf

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Information on this page was last updated on 30 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.