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Metapro CL Tablet
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Metapro CL Tablet

Manufactured byMICRO LABS LTD
ContainsCilnidipine (10 mg) + Metoprolol (50 mg)
Description
Metapro CL Tablet is a combination medicine used for the treatment of high blood pressure. Patients are advised to maintain a strict exercise and diet regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients below 18 years of age.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Metapro CL Tablet

  • Chest pain and discomfort
  • Decreased blood pressure
  • Blurred vision
  • Dizziness
  • Irregular heartbeat
  • Shortness of breath
  • Nausea or vomiting
  • Skin rash
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Muscle pain
  • Shaking of hands or feet
  • Decreased sexual urge
  • Increased urination frequency
  • Stomach pain
  • Diarrhea

Uses of Metapro CL Tablet

What is it prescribed for?

  • Hypertension (increased blood pressure)
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment of this medicine due to the increased risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in people with a known allergy to cilnidipine, metoprolol, other beta-blockers, or any other inactive ingredients present in the formulation.

Heart diseases

This medicine is not recommended for use in patients having heart conditions like heart attack, rhythm disorders, angina, sick sinus syndrome, narrowing of blood vessels, etc.

Circulatory disorders

This medicine is not recommended for use in people suffering from blood circulation disorders or cardiogenic shock due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Heart Failure

Use of this medicine decreases cardiac function and reduced flow of blood especially in people having a heart disorder causing heart failure. Suitable dose adjustment and safety monitoring might be required based on the severity of the disease.

Ischemic Heart Disease

Use of this medicine should not be discontinued abruptly in patients with Ischemic heart disease. The dosage should be gradually reduced over a period of 1 to 2 weeks.

Major surgery

This medicine should be given with caution to patients who are going to undergo major surgery. The dose should be very carefully monitored in such cases both before and after the surgical procedure.

Pheochromocytoma

This medicine should be administered with extreme caution in patients suffering from pheochromocytoma, a condition which results in an excess of a substance that controls heartbeat and blood pressure. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Bronchospastic Disease

This medicine should be administered with caution in patients with a disease of the lung or the airways leading to the lungs such as pneumonia, asthma, or chronic obstructive pulmonary disease. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes and Hypoglycemia

This medicine should be administered with caution in patients having elevated blood sugar levels.This medicine may mask certain symptoms of hypoglycemia which may cause serious adverse effects.

Thyrotoxicosis

This medicine should be administered with caution in patients having elevated thyroid hormone levels. Some adverse effects may not be evident in these cases and abrupt stopping of this medicine may cause an abnormal rise in thyroid hormones.

Peripheral Vascular Diseases

This medicine should be used with caution in patients having narrowed blood vessels in the body due to any underlying reason. Dose adjustment and safety monitoring might be required in such cases.

Other Medicines

This combination medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Sports

It is advised to not indulge in certain sports while this medicine is consumed. Archery, racing, shooting and other high-risk sports should be avoided. Sports-persons should refer to the list of medicine published by World Anti-Doping Agency which is not to be taken while participating in specific sports events.

Hypotension

This medicine should be used with extreme caution in patients suffering from aortic stenosis due to the increased risk of very low blood pressure. Close monitoring of blood pressure is recommended for such patients. An alternative treatment option should be considered in some cases based on the clinical condition.

Heart attack

This medicine should be used with caution while starting or increasing the dose in patients with coronary artery diseases as it may worsen the symptoms of a heart attack.

Liver Disease

This medicine should be used with extreme caution in patients having an impaired liver function due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug Withdrawal

Abrupt discontinuation of this medicine may increase the risk of increased chest pain (angina). A gradual dose reduction is recommended to avoid these reactions. Do not stop the use of this medicine without consulting your doctor.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment of this medicine due to the increased risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Amlodipine

Carbamazepine

Diltiazem

Aminophylline

Ergotamine

Primaquine

Cimetidine

Disease interactions

Asthma

This medicine is not recommended for use in patients with a history of bronchial asthma or chronic obstructive pulmonary disease since it may worsen the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.

Heart Block

This medicine is not recommended for use in patients with a greater than first-degree heart block unless a permanent pacemaker is present due to the increased risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

High cholesterol and fat

This medicine should be used with caution in patients with high levels of cholesterol and fat due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypotension or cardiogenic shock

This medicine is not recommended for use in patients with low blood pressure or cardiogenic shock as it may further lower the blood pressure causing severe adverse effects. An alternative treatment option should be considered based on the clinical condition.

Congestive heart failure

This medicine should be used with extreme caution in patients with congestive heart failure since it may worsen the patient's condition. Close monitoring of blood pressure, electrolytes level, and heart function are recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended while taking this medicine due to the increased risk of adverse effects. Symptoms like dizziness, headache, swelling of hands and feet should be reported to the doctor on priority.
The desired effect of this medicine may not be achieved if taken along with multivitamins and minerals.. Close monitoring of blood pressure and appropriate dose adjustments may be necessary in some cases based on the clinical condition. Your doctor may advise you to maintain an appropriate time gap between the consumption of multivitamin with minerals and this medicine to minimize their interaction.
Lab interactions

Urinary vanillylmandelic acid

Report the use of this medicine if you have been asked to undergo this test for the presence of adrenal gland tumor. Use of this medicine is likely to give false value that might be higher than normal.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Cilnidipine acts by blocking the influx of calcium (responsible for contraction of blood vessels) and causes relaxation, thereby promoting the smooth flow of blood. Metoprolol works by relaxing the blood vessels and slowing the heartbeat. This results in improved blood flow to the heart and the blood pressure is lowered.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Cardioselective beta blockers with calcium channel blocker

Schedule

Schedule H

K. Sarat Chandra G. The fourth-generation Calcium channel blocker: Cilnidipine [Internet]. PubMed Central (PMC). 2017 [cited 23 March 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905258/

[Internet]. Centaurpharma.com. 2017 [cited 16 November 2017]. Available from:

http://www.centaurpharma.com/newwebsite/downloads/CENTAPRES.pdf

[Internet]. Stridesarco.com. 2019 [cited 11 January 2019]. Available from:

http://www.stridesarco.com/pdf/Branded/india/cardiac_care/neodipine_m.pdf

Metoprolol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 15 May 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682864.html
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Information on this page was last updated on 14 May 2019

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