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Megapime XP 1 g Injection
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Megapime XP 1 g Injection

Manufactured byALKEM LABORATORIES LTD
ContainsCefipime (1000 mg) + Tazobactam (125 mg)
Description
Megapime XP 1 g Injection is a combination of Cefipime and Tazobactam. It is used to treat various types of bacterial infections. The medicine works by preventing the growth of bacteria. Megapime XP 1 g Injection has some side effects like nausea, vomiting, diarrhoea, pain at the site of injection, etc. These side effects may subside by themselves. Consult your doctor if they persist for a long time or become severe. Megapime XP 1 g Injection is administered in a hospital setting by a qualified healthcare professional. Do not miss any appointments with your doctor. Complete the course of treatment even if you feel better. Megapime XP 1 g Injection is not recommended for use if you are allergic to it. Inform your doctor if you have liver or kidney problems including all the health issues and medicines you use. Consult your doctor if you are pregnant or are breastfeeding before taking this medicine.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Megapime XP 1 g Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Bleeding gums
  • Fever
  • Headache
  • Yellowing of skin and eyes
  • Swelling of foot
  • Redness of skin
  • Pain at the injection site
  • Sour mouth

Uses of Megapime XP 1 g Injection

What is it prescribed for?

  • Bacterial infections
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required by Megapime XP 1 g Injection to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Megapime XP 1 g Injection remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Megapime XP 1 g Injection.
  • Can this medicine be taken during pregnancy?
    Megapime XP 1 g Injection is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Megapime XP 1 g Injection is not recommended for use in breastfeeding women unless absolutely necessary. Consult your doctor if you are breastfeeding.

Allergy

Avoid taking Megapime XP 1 g Injection if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Megapime XP 1 g Injection is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor if you are pregnant.

Breast-feeding

Megapime XP 1 g Injection is not recommended for use in breastfeeding women unless absolutely necessary. Consult your doctor if you are breastfeeding.
General warnings

Clostridium difficile-associated diarrhoea

Megapime XP 1 g Injection may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhoea. Your doctor may discontinue the medicine if severe diarrhoea occurs after its use.

Drug-resistance

Usage of Megapime XP 1 g Injection without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of the development of bacteria that are drug-resistant (not affected by the medicine).

Neurotoxicity

Megapime XP 1 g Injection may increase the risk of serious side effects such as encephalopathy (altered brain function), seizures (fits), and nonconvulsive status epilepticus (altered mental state) in some people. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to your doctor on priority.

Hypersensitivity reactions

Megapime XP 1 g Injection may cause serious and occasionally fatal hypersensitivity reactions in some people. This risk is especially higher in people with a history of sensitivity to multiple allergens. Report any allergic symptoms such as a rash, itching, nausea or vomiting, swelling of the lips, hands, and feet, etc. to your doctor immediately.

Missed Dose

Since Megapime XP 1 g Injection is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor immediately for further instructions.

Overdose

SinceMegapime XP 1 g Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Ethinyl Estradiol

Cholera Vaccine

Furosemide

Probenecid

Entecavir

Disease interactions

Kidney dysfunction

Use Megapime XP 1 g Injection with caution if you have a history of kidney disorder due to the increased risk of serious side effects. Your doctor may suggest tests to closely monitor kidney function if necessary while receiving this medicine.

Gastrointestinal Diseases

Use Megapime XP 1 g Injection with caution if you have gastrointestinal disorders (stomach and intestinal disorders), particularly colitis (swelling of the colon), since it may worsen the health condition. Report any incidence of severe diarrhoea, abdominal pain, blood in stools, etc. to your doctor immediately.

Impaired liver function

Use Megapime XP 1 g Injection with caution if you have a liver disorder due to the increased risk of severe side effects. Report any undesired side effects to your doctor on priority. Your doctor may suggest tests to closely monitor liver function if necessary while receiving this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Megapime XP 1 g Injection should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform your doctor if you have an allergy to this medicine. Report to your doctor all your current medicines, including any herbs and supplements, as well as your medical conditions before receiving this medicine. Report any undesired effects to your doctor on priority.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Megapime XP 1 g Injection is a combination of Cefipime and Tazobactam. Cefipime works by interfering with bacterial cell wall synthesis. Tazobactam inhibits some of the chemicals produced by the bacteria and makes the bacteria more sensitive to cefepime activity. Thus, their combination becomes effective against an extended range of bacteria.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Fourth generation Cephalosporins, Beta-lactamase inhibitors, Cephalosporins/beta-lactamase inhibitors

Schedule

Schedule H

CiplaMed. 2021. FORPAR XP Injection. [online] Available at: [Accessed 18 October 2021].

https://ciplamed.com/content/forpar-xp-injection

Drugs, H., 2021. Cefepime Injection: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: [Accessed 18 October 2021].

https://medlineplus.gov/druginfo/meds/a698021.html

Pubchem.ncbi.nlm.nih.gov. 2021. Tazobactam. [online] Available at: [Accessed 18 October 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Tazobactam#section=Biological-Half-Life
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Information on this page was last updated on 2 Feb 2023

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