Mannitol

Description

Mannitol is an osmotic diuretic used to remove excess water and toxins from the body in patients with kidney disease. It is also used in the treatment of cerebral edema and intraocular pressure. Frequent monitoring of electrolytes levels is necessary during treatment with this medicine.

Side effects

Major & minor side effects for Mannitol

  • Headache
  • Dry mouth
  • Dehydration
  • Fluid and electrolyte imblance
  • Chest pain
  • Dizziness
  • Blurred vision
  • Nausea
  • Fast or irregular heartbeat
  • Reduced food intake
  • Uncontrolled shaking of arms or legs
  • Urinary incontinence

Uses of Mannitol

What is it prescribed for?

  • Cerebral edema (Fluid accumulation in cerebral cavity)
  • Oliguria (Low urine output)
  • Intraocular pressure (Fluid pressure inside the eye)
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Concerns

Commonly asked questions

  • Onset of action
    The estimated amount of time required for this medicine to show its effect is about 1 to 3 hours for diuresis, 30 to 60 minutes for lowering intraocular pressure, and 15 minutes for the reduction of intracranial pressure.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 3 to 8 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine should be used with caution in breastfeeding women. Discuss all the risks and benefits with your doctor before receiving this medicine.

Anuria

This medicine is not recommended for patients with a known history of anuria (a condition where the kidney is unable to produce urine).

Severe pulmonary edema (Fluid accumulation in lungs)

This medicine is not recommended for use in patients with a known history of severe pulmonary edema.

Progressive heart failure

This medicine is not recommended for use in patients with a known history of progressive heart failure caused by Mannitol therapy.

Intracranial bleeding (Bleeding inside the skull)

Patients with a known history of intracranial bleeding are recommended not to take this medicine.

Severe dehydration

This medicine is not recommended for use in patients with severe dehydration.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine should be used with caution in breastfeeding women. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Volume and electrolyte depletion

Mannitol may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolytes levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

Allergy

This medicine is not recommended for use in patients with a known allergy to Mannitol.

Crystallization of solutions

This medicine may crystallize when exposed to low temperatures. If crystals are visible, they can be dissolved by warming the solution in a hot water bath or a warming cabinet, followed by gentle agitation (shaking of the vial). Once crystals dissolve, allow the solution to cool to room temperature, reinspect for crystals, and use if crystals are not visible. The medicine should not be used if crystals are present. Please note that the method of warming may differ based on the manufacturer's recommendations.

Missed Dose

Since this medicine is administered in the clinical/hospital set up by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the clinical/hospital set up by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be provided by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aminoglycoside antibiotics

Salbutamol

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Mannitol will be administered by your doctor or a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have an allergy to this medicine. Report all your current medicines as well as your medical history to the doctor. This medicine is usually given at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary during treatment with this medicine. This medicine should be used with caution due to the increased risk of dizziness.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by decreasing the reabsorption of water through the kidneys and increasing the urine output. This helps in reducing the swelling in conditions like cerebral edema.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous diuretics

Schedule

N/A

DailyMed - Mannitol injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=74e9108e-8540-4442-82bc-4f46c6bdd334

Mannitol - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00742

[Internet]. 2017 [cited 21 July 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/30188

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 21 July 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

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Information on this page was last updated on 8 Jul 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.