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Malirid 2.5 mg Tablet DT

Manufactured byIpca Laboratories Pvt. Ltd.
ContainsPrimaquine
Description

Malirid 2.5 mg Tablet DT is an antimalarial medication used for the prevention and treatment of malaria. It is particularly effective in treating malaria caused by Plasmodium vivax and Plasmodium ovale strains of the parasite. It is also used to prevent the relapse (Radical cure) of vivax malaria.

Side effects

Major & minor side effects for Malirid 2.5 mg Tablet DT

  • Nausea and Vomiting
  • Heartburn
  • Abdominal pain and cramps
  • Hemolytic anemia (G6PD deficiency)
  • Headache
  • Unusual tiredness and weakness
  • Difficulty in breathing
  • Yellowing of skin and eyes
  • Fast heartbeat
  • Nervousness and confusion
  • Grey-bluish colored skin
  • Blurred vision
  • Sore throat and fever
  • Dizziness and fainting
  • Reduced blood cell count

Uses of Malirid 2.5 mg Tablet DT

What is it prescribed for?

  • Malaria
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken for this medicine to show its effect is not established clinically.
  • How long do the effects of this medicine last?
    The duration of time for which this medicine remains effective in the body is not established clinically.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known history of allergy to Primaquine, other 8-aminoquinoline compounds or any other inactive ingredients present in the formulation.

Granulocytopenia

This medicine is not recommended for use in acutely ill patients suffering from systemic diseases like rheumatoid arthritis and lupus erythematosus. There is a marked decrease in the number of granulocytes in such conditions.

Hemolytic and bone marrow depressant drugs

This medicine is not recommended for use if you are receiving a medication that can cause anemia or suppression of the immune system by affecting bone marrow cells as a side effect.

Quinacrine

This medicine is not recommended for use in patients consuming Quinacrine or any other combination medicine containing quinacrine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Regular blood examination

Use of this medicine can critically affect the blood cell count and cause anemia, leukopenia, and disorders of the blood. Hence, it is recommended to undergo regular blood examination while taking this medicine. Before initiating the treatment process with this medicine, patients should be examined for blood enzyme deficiencies.

Heart diseases

Use of this medicine can affect the heart and worsen the symptoms of a pre-existing condition. It is advised to monitor such patients at regular intervals. Use of other medicines having a similar effect on the heart should be avoided. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases.

Radical treatment of malaria

For radical treatment of malaria, this medicine should be used in combination with other anti-malaria medications that are effective against parasites present in the blood.

Other medicines

Report the use of all other medicines including herbs and supplements to the doctor before receiving Primaquine. The potential for interaction with other medicines is very high.

Drug resistance

It is recommended to take this medicine for the entire prescribed duration even when symptoms improve or resolve. Failure to do so might result in drug resistance and treating any subsequent infection with the same medicine would be very difficult.

Prolongation of QT interval

Use of this medicine may increase the risk of irregular heart rhythms. Therefore, it should be used with caution in patients with arrhythmias or any other heart disease. Any symptoms of palpitations, difficulty in breathing should be reported to the doctor. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose. Symptoms of an overdose with this medicine may include vomiting, heartburn, stomach pain and cramps, pale skin, bluish lips, and fingernails, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Escitalopram

Sodium Nitrite

Prilocaine

Etanercept

Doxepin

Azithromycin

Amitriptyline

Erythromycin

Chloroquine

Salbutamol

Disease interactions

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients having hemolytic anemia due to the deficiency of G6PD enzymes. The risk of severe adverse effects is significantly high in such cases. An alternative treatment option should be considered based on clinical conditions.

Methemoglobinemia/NADH methemoglobin reductase deficiency

This medicine is not recommended for use in patients having methemoglobinemia caused due to the deficiency of the NADH-methemoglobin reductase enzyme. The risk of life-threatening adverse effects is significantly high in such cases. An alternative treatment option should be considered based on clinical conditions.

Granulocytopenia

This medicine is not recommended for use in patients suffering from systemic diseases that cause a decrease in the blood cell component called granulocytes. This results in a reduction of immune system capabilities due to depression of bone marrow cells. Some of the most common diseases are Rheumatoid arthritis, leukopenia, etc. An alternative treatment option should be considered based on clinical conditions.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as advised by your doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by inhibiting the growth and development of the malarial parasite present in the body.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antimalarial Quinolines

Schedule

Schedule H

Primaquine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 12 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB01087

Primaquine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 12 June 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a607037.html
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Information on this page was last updated on 26 Feb 2020

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