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Madopar 250 Tablet
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Madopar 250 Tablet

Manufactured byABBOTT HEALTHCARE PVT LTD
ContainsLevodopa (200 mg) + Benserazide (50 mg)
Description
Madopar 250 Tablet is a combination medicine which may be used to treat the symptoms of Parkinson's disease in adults above 25 years of age. These symptoms may include shakiness, stiffness, and slowness of movement which are usually caused by a lack of dopamine, a natural substance present in the brain. It is not recommended for use in the treatment of drug-induced parkinsonism.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Madopar 250 Tablet

  • Nausea or Vomiting
  • Dizziness
  • Back pain
  • Muscle rigidity
  • Drowsiness or sleepiness
  • Itching or rash
  • Confusion
  • Twitching
  • Uncontrolled muscle movements
  • Fainting
  • Headache
  • Trouble concentrating
  • Lack of hunger
  • Feeling sad or empty
  • Nervousness
  • Diarrhea
  • Abdominal and stomach pain
  • Irregular heartbeat
  • Depression

Uses of Madopar 250 Tablet

What is it prescribed for?

  • Parkinson's Disease
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 15 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 5 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to levodopa, benserazide or any other inactive ingredients present in the formulation.

Narrow angle glaucoma

This medicine is not recommended for use in patients with a known history of narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.

Nonselective monoamine oxidase inhibitors (MAOIs)

This medicine is not recommended for use in patients who are taking nonselective monoamine oxidase inhibitors (MAOIs) or have taken these medicines in the past 14 days due to the increased risk of severe drug-drug interactions. It is advised that patients should inform the doctor about all their current medicines including herbs and supplements before beginning therapy with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
General warnings

Driving Or Operating machinery

Use of this medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Hallucinations

This medicine should be used with caution due to an increased risk of severe side effects such as hallucinations, psychotic episodes, and confusion. The risk is especially higher in elderly patients. Close monitoring of patients for any changes in mood and behavior is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine.

Compulsive Behaviors

This medicine should be used with caution due to the increased risk of impulsive or compulsive behaviors. These may include an intense urge to gamble, binge eat, or spend money. Close monitoring of patients for any change in behavior and mood is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition.

Falling asleep during daily activities

This medicine should be used with caution due to the increased risk of side effects such as dizziness, fainting, and drowsiness. This may cause you to fall asleep during your day-to-day activities. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Aceclofenac

Nitrofurantoin

Amiodarone

Atazanavir

Captopril

Bupropion

Amikacin

Atorvastatin

Furosemide

Azathioprine

Aripiprazole

Disease interactions

Hypotension

Use of this medicine may increase the risk of orthostatic hypotension. This risk is especially higher in patients receiving high blood pressure medicines and elderly patients. Close monitoring of blood pressure may be necessary for such patients based on the clinical condition. Patients are advised to get up slowly from a sitting or a lying position to avoid fainting and falling. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Depression

This medicine should be used with caution in patients with a known history of depression due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any changes in behavior and mood. Replacement with a suitable alternative may be necessary based on the clinical condition.

Neuroleptic Malignant Syndrome

This medicine is not recommended for use in patients with a history of Neuroleptic Malignant Syndrome due to the increased risk of severe side effects. These side effects may include altered mental status, hyperthermia, and irregular pulse or blood pressure. Close monitoring of patients for any unusual symptoms is necessary. Replacement with a suitable alternative may be done based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as instructed by the doctor. Do not take larger amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Levodopa gets converted into a chemical substance (dopamine) in the brain and relieves the symptoms of Parkinson's disease. Benserazide prevents the breakdown of levodopa in the bloodstream and the stomach, which is effective in increasing the amount of levodopa available for transport to the brain.
Legal Status

Unknown

Unknown

Unknown

Approved

Classification

Category

Decarboxylase inhibitors, Dopaminergic Antiparkinsonism agents

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2019 [cited 25 April 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.1111.pdf

[Internet]. 2019 [cited 25 April 2019]. Available from:

https://medsafe.govt.nz/profs/Datasheet/m/Madoparcapdisptab.pdf

Levodopa - DrugBank [Internet]. Drugbank.ca. 2017 [cited 12 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01235

Benserazide - DrugBank [Internet]. Drugbank.ca. 2019 [cited 22 April 2019]. Available from:

https://www.drugbank.ca/drugs/DB12783

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2019 [cited 25 April 2019]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-02391-3&d=201904251016933
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Information on this page was last updated on 9 Aug 2019

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