Home >
Medicine Info >
Maczone XP 250 Injection
Loading interface...

Maczone XP 250 Injection

Manufactured byMACLEODS PHARMACEUTICALS PVT LTD
ContainsCeftriaxone (250 mg) + Tazobactam (31.25 mg)
Description
Maczone XP 250 Injection is a combination medicine used to treat a variety of bacterial infections such as community-acquired pneumonia, lower respiratory tract infections, urinary tract infections, skin and skin structure infections, etc. caused by susceptible bacteria. This medicine should be used with caution in patients less than 12 years of age.
QUICK LINKS:
Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Maczone XP 250 Injection

  • Nausea
  • Vomiting
  • Black or tarry stools
  • Chest pain
  • Fever
  • Difficulty or painful urination
  • Sore throat
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Acid or sour stomach
  • Change in taste
  • Excessive air or gas in stomach

Uses of Maczone XP 250 Injection

What is it prescribed for?

  • Bacterial infections
  • Lower Respiratory Tract Infection
  • Community-Acquired Pneumonia
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine occurs rapidly after an intravenous or an intramuscular administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to ceftriaxone, tazobactam, other beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.

Lidocaine

This medicine is contraindicated for use if Lidocaine is used as a solvent for intravenous injection. Lidocaine can be used as a solvent for the intramuscular injection, despite contraindications, in certain specific conditions.

Calcium-containing products

This medicine is contraindicated for use in neonates who are receiving calcium-containing intravenous solutions or infusions such as parenteral nutrition due to the increased risk of precipitation of this medicine and calcium.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Hemolytic anemia

An immune mediated hemolytic anemia has been reported in patients receiving this medicine. Report any unusual symptoms to the doctor immediately. Your doctor may advise you to discontinue the medicine if you develop hemolytic anemia until the exact cause is determined.

Prothrombin time

Alterations in prothrombin time (a test used to check for bleeding problems) have been reported in patients receiving this medicine. Regular monitoring of prothrombin time is required while receiving this medicine. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Patients with impaired kidney and liver function

This medicine should be used with caution in patients with kidney and liver diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney and liver function tests may be necessary while receiving this medicine. The dose of this medicine should not exceed 2 g/day (ceftriaxone) for such patients.

Clostridium difficile-associated Diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of bacteria called Clostridium difficile and patients may experience severe diarrhea as a result. Report any such incidence to the doctor on priority and avoid usage of this medicine in such cases.

Use in Children

This medicine should be used with caution in patients less than 12 years of age due to the increased risk of severe adverse effects. Your physician may prescribe this medicine for certain specific indications based on the body weight and clinical condition.

Administration

When used intravenously, this medicine should be infused over a duration of at least 30 to 60 minutes. When used intramuscularly, the medicine should be injected over a duration of 2 to 4 minutes.

Missed Dose

Since this medicine is administered in the hospital/clinical setting by a qualified health-care professional, the likelihood of a missed dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor for further instructions.

Overdose

Since this medicine is administered in the hospital/clinical setting by a qualified health-care professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Ethinyl Estradiol

Cholera Vaccine

Cyclosporine

Probenecid

Entecavir

Disease interactions

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients with a history of seizure disorders or a family history of seizures since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Direct Coombs test

Report the use of this medicine to the doctor if you are undergoing the Coombs test. A false positive result may be obtained if this test is performed while receiving this medicine. Do not stop the use of any medicine without consulting your doctor.

Urine Glucose

Report the use of this medicine to the doctor if you are undergoing a urine glucose/sugar test. A false positive result may be obtained if this test is performed while receiving this medicine. An alternative test may be considered to evaluate glucose levels. Do not stop the use of any medicine without consulting your doctor.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
This medicine should be administered by a qualified health-care professional in the hospital/clinical setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines, including any herbs and supplements, as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Ceftriaxone works by interfering with certain processes that help the bacteria to grow and increase in number. Tazobactam inhibits some chemicals produced by the bacteria and makes the bacteria more sensitive to ceftriaxone activity. Thus, their combination is better effective for the treatment of a wide range of bacterial infections.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Third generation cephalosporins, Beta-lactamase inhibitors

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 8 August 2018]. Available from:

https://ciplamed.com/content/cefoprox-xp-injection

Tazobactam - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB01606

DailyMed - Ceftriaxone sodium injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 8 October 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5d7ae2f-5485-42e2-af2b-bd7f06df85d7&audience=consumer

Zuventus Healthcare [Internet]. Zuventus.co.in. 2018 [cited 8 August 2018]. Available from:

http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=67
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 8 Oct 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.