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Macpril H (12.5/5 mg) Tablet

Manufactured by: Macleods Pharmaceuticals Pvt. Ltd.
Composition: Hydrochlorothiazide (12.5 mg) + Ramipril (5 mg)
Prescription Required: Yes
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Description

Macpril H (12.5/5 mg) Tablet is a combination medicine used in the treatment of mild to moderate hypertension. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Macpril H (12.5/5 mg) Tablet

  • Increased urinationsevere
  • Itching or rashsevere
  • Abdominal and stomach pain
  • Dry mouthsevere
  • Joint pain, stiffness, and swelling
  • Cramping
  • Blurred visionsevere
  • Sweatingsevere
  • Dizzinesssevere
  • Unusual tiredness and weaknesssevere
  • Back painsevere
  • Chest tightnesssevere
  • Increased heartbeatsevere
  • Cough
  • Diarrhea
  • Vomiting
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Macpril H (12.5/5 mg) Tablet

Onset of action

The effect of this medicine can be observed within 2 hours of administration of the dose.

Duration of effect

The effect of this medicine lasts for an average duration of 24 hours.

Safe with alcohol?

moderate
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.

Is it habit forming?

No habit forming tendency has been reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

What is it prescribed for?

Uses of Macpril H (12.5/5 mg) Tablet

  • Mild to moderate hypertension

    This medicine is used in the treatment of high blood pressure which may be caused by genetic or environmental factors.

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When not to use?

Contraindications of Macpril H (12.5/5 mg) Tablet

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to ramipril, other ACE inhibitors, hydrochlorothiazide, or other sulfonamides.

  • Anuria

    This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

  • Severe liver impairment

    This medicine is not recommended for use in patients with a known history of severe liver diseases due to the increased risk of worsening of the patient's condition.

  • Renal artery stenosis

    This medicine is not recommended for use in patients with a known history of renal artery stenosis since it may worsen the patient's condition.

  • Severe renal impairment

    This medicine is not recommended for use in patients with severe renal impairment (CrCl =< 30 ml/min/1.7 m2) due to the increased risk of serious adverse effects.

  • Aliskiren

    Coadministration of aliskiren and this combination medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Dosage

  • Missed Dose

    The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcoholmoderate

  • Description

    - N/A

  • Instructions

    - Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.

Interaction with Medicine

  • Losartansevere
  • Corticosteroidsmoderate
  • Aliskirensevere
  • Insulinmoderate
  • Antidepressantsmoderate
  • Nonsteroidal anti-inflammatory medicinesmoderate

Disease interactions

  • Diabetes

    moderate
    This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

  • Hyperuricemia

    moderate
    This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

  • Angioedema

    severe
    This medicine is not recommended for use in patients with a history of angioedema or a family history of angioedema due to the increased risk of recurrent symptoms. Report any incidence of swelling of the face, lips, and eyes to the doctor on priority. Replacement with a suitable alternative may be required based on the clinical condition.

Food interactions

  • Information not available.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General warnings

  • Hepatic dysfunction

    - This medicine should be used with extreme caution in patients with liver dysfunction due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition.

  • Volume and electrolyte depletion

    - This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Renal diseases

    - This medicine may cause Azotemia in patients with a known history of severe renal diseases. Close monitoring of kidney function is necessary while taking this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

  • Hyperkalemia

    - This medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

  • Pediatric population

    - This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

  • Cough

    - This medicine may cause a persistent nonproductive cough in some patients. It is resolved when the medicine is discontinued.

  • Driving and operating machines

    - This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience these symptoms during treatment with this medicine.

  • Hypotension

    - Symptomatic hypotension may occur in patients with volume depletion or patients who are treated with high-dose diuretics. It is advised to correct this condition before initiating treatment with this combination medicine.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken in morning
  • May cause sleepiness

How it works

Hydrochlorothiazide increases the excretion of water and sodium through the urine. Ramipril relaxes the blood vessels and promotes the smooth flow of blood.

Legal Status

Approved
Unknown
Approved
Unknown

Classification

Category
Angiotensin converting enzyme inhibitors, Thiazide diuretics, ACE inhibitors with thiazides, Antihypertensive combinations
Schedule
Schedule H

References

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Information on this page was last updated on 9 Oct 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.