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Macox ZH Tablet
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Macox ZH Tablet

Manufactured byMACLEODS PHARMACEUTICALS PVT LTD
ContainsRifampicin (225 mg) + Isoniazid (150 mg) + Pyrazinamide (750 mg)
Description
Macox ZH Tablet is a combination of Rifampicin, Pyrazinamide and Isoniazid. This medicine is used for the treatment of tuberculosis (a bacterial infection that affects your lungs). It prevents the bacteria from growing, thus it helps in treating the infection. Macox ZH Tablet might cause some side effects like nausea, vomiting, headache, heartburn, etc., that subside with time. Avoid consuming alcohol while you are on treatment with this medicine because it may cause excessive drowsiness. Inform your doctor if any of the side effects become severe or persist for a long time. Macox ZH Tablet is recommended to be taken on an empty stomach. Abrupt discontinuation may cause the infection to reappear. It may take some time for the medication to show its effects. However, if you notice a worsening of your condition or if it does not improve, consult your doctor. Macox ZH Tablet should be used with caution if you have liver and stomach/intestinal problems. Inform your doctor about any other medications you are taking because some may interact with or be impacted by this medication. If you are pregnant or are breastfeeding, consult your doctor before taking this medicine.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Macox ZH Tablet

  • Abdominal pain
  • Dizziness
  • Headache
  • Yellow colored eyes or skin
  • Skin rash
  • Muscle pain
  • Dark urine
  • Loss of appetite
  • Nausea or vomiting
  • Unusual tiredness or weakness
  • Tingling or numbness of the hands and feet
  • Depression
  • Joint pain
  • Unusual bleeding or bruising

Uses of Macox ZH Tablet

What is it prescribed for?

  • Tuberculosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Macox ZH Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Macox ZH Tablet remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid drinking alcohol while on treatment with Macox ZH Tablet as it may increase the risk of side effects such as dizziness, flushing, increased heartbeat, nausea, thirst, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Macox ZH Tablet.
  • Can this medicine be taken during pregnancy?
    Macox ZH Tablet is not recommended for use if you are pregnant. It may cause harm to your foetus; hence, consult your doctor before using it.
  • Can this medicine be taken while breast-feeding?
    Macox ZH Tablet passes into breastmilk. Thus, it is not recommended for use if you are breastfeeding.

Allergy

If you have a known allergy to Macox ZH Tablet, avoid this medication. Seek immediate medical attention if you notice any symptoms of allergic reactions such as a skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Antiviral medications

Macox ZH Tablet is not recommended for use if you are receiving antiviral treatment This medicine can decrease the effectiveness of antiviral medicines and may lead to viral resistance.

Severe liver impairment

Macox ZH Tablet should be used with caution if you have any liver conditions. This medicine is broken down in your liver, and improper liver function can lead to the accumulation of this medicine in your body. This may worsen your condition.
Warnings for special population

Pregnancy

Macox ZH Tablet is not recommended for use if you are pregnant. It may cause harm to your foetus; hence, consult your doctor before using it.

Breast-feeding

Macox ZH Tablet passes into breastmilk. Thus, it is not recommended for use if you are breastfeeding.
General warnings

Use in children

Macox ZH Tablet is not recommended for use in children below 15 years of age due to the lack of safety and efficacy of its use.

Diabetes

Macox ZH Tablet should be used with caution if you have diabetes (a condition in which the blood sugar level increases). This medicine may alter your blood sugar levels and affect the management of diabetes.

Drug-resistance

Usage of Macox ZH Tablet without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of the development of bacteria that are drug-resistant.

Kidney Disease

Macox ZH Tablet should be used with caution if you have any medical conditions affecting your kidneys. Any kidney dysfunction can lead to its accumulation of the medicine in your body. This may worsen your condition.

Liver enzymes

Macox ZH Tablet may elevate liver enzyme levels. Use it with caution and get your liver function tests done regularly.

Missed Dose

If you have missed Macox ZH Tablet dose, make sure that you remember to take the next dose on time. Do not take two doses together to make up for a missed dose.

Overdose

Never take Macox ZH Tablet more than the prescribed dose. If you suspect that you have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid drinking alcohol while on treatment with Macox ZH Tablet as it may increase the risk of side effects such as dizziness, flushing, increased heartbeat, nausea, thirst, etc.
Interaction with Medicine

Warfarin

Atorvastatin

Clopidogrel

Disease interactions

Colitis

Colitis is swelling of the colon (a part of your intestine). Macox ZH Tablet should be used with caution if you have colitis. This medicine may cause the infection to flare up, thus can worsen your condition.

Hematopoietic disturbances

Hematopoietic disturbances are disorders that primarily affect the blood & blood-forming organs like bone marrow. Take Macox ZH Tablet with extreme caution as it may worsen your condition.

Porphyria

Porphyria is a blood disorder that is caused due to build-up of certain chemicals related to red blood cell proteins. Take Macox ZH Tablet with extreme caution as it may worsen your condition.
Food interactions
Macox ZH Tablet should be taken on an empty stomach, at least one hour before or two hours after a meal because food decreases the absorption of this medicine.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Macox ZH Tablet on an empty stomach, either one hour before or two hours after a meal. Do not consume in larger or smaller amounts than advised. Consult your doctor if you experience any undesirable effects. It may cause discolouration (yellow, orange, red, brown) of your teeth, urine, sweat, sputum, and tears. Soft contact lenses may be permanently stained. This is normal and not harmful.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Macox ZH Tablet is a combination of three medicines, Rifampicin Pyarazinamide and Isoniazid. Rifampicin acts by blocking the action of a bacterial component, which is necessary for tuberculosis bacteria to multiply. Isoniazid prevents the growth of the protective layer of these bacteria. They work together to kill the bacteria and treat the infection. Pyrazinamide shows its action by altering the pH in the cell and stopping the growth of the organism.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antituberculosis combinations

Schedule

Schedule H

Drugs, H., 2021. Isoniazid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 31 August 2021].

https://medlineplus.gov/druginfo/meds/a682401.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Isoniazid. [online] Available at: < [Accessed 31 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/3767>

Dailymed.nlm.nih.gov. 2021. RIFAMATE® (rifampin and isoniazid capsules USP). [online] Available at: < [Accessed 31 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc36609-8e2d-4caa-a8e0-c0367e3e52df>

Pubchem.ncbi.nlm.nih.gov. 2021. Pyrazinamide. [online] Available at: < [Accessed 14 April 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Pyrazinamide>

Drugs, H., 2021. Rifampin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 31 August 2021].

https://medlineplus.gov/druginfo/meds/a682403.html>

Drugs, H., 2021. Pyrazinamide: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 18 November 2021].

https://medlineplus.gov/druginfo/meds/a682402.html>
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Information on this page was last updated on 14 Mar 2023

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