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Macox Plus Tablet
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Macox Plus Tablet

Manufactured byMacleods Pharmaceuticals Pvt. Ltd.
ContainsRifampicin (450 mg) + Isoniazid (300 mg)
Description
Macox Plus Tablet is a combination of Rifampicin and Isoniazid. This medicine is used for the treatment of tuberculosis (a bacterial infection that affects your lungs). It prevents the bacteria from growing, thus it helps in treating the infection. Macox Plus Tablet might cause some side effects like nausea, vomiting, headache, heartburn, etc., that subside with time. Avoid consuming alcohol while you are on treatment with this medicine because it may cause excessive drowsiness. Inform your doctor if any of the side effects become severe or persist for a long time. Macox Plus Tablet is recommended to be taken on an empty stomach. Abrupt discontinuation may cause the infection to reappear. It may take some time for the medication to show its effects. However, if you notice a worsening of your condition or if it does not improve, consult your doctor. Macox Plus Tablet should be used with caution if you have liver and stomach/intestinal disease. Inform your doctor about any other medications you are taking because some may interact with or be impacted by this medication. If you are pregnant or are breastfeeding, consult your doctor before taking this medicine.
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Side effectsConcernsUsage

Substitutes

List of substitutes for Macox Plus Tablet

Mycocox Tablet
Cadila Pharmaceuticals Ltd.
AKT 2 TABLET
Lupin Ltd.

Side effects

Major & minor side effects for Macox Plus Tablet

  • Heartburn
  • Headache
  • Nausea or Vomiting
  • Increased menstrual flow
  • Tingling or numbness of the hands and feet
  • Bloating
  • Dark colored urine
  • Skin Rash
  • Dizziness
  • Yellowing of skin and eyes

Uses of Macox Plus Tablet

What is it prescribed for?

  • Tuberculosis
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Macox Plus Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Macox Plus Tablet remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid drinking alcohol while on treatment with Macox Plus Tablet as it may increase the risk of side effects such as dizziness, flushing, increased heartbeat, nausea, thirst, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Macox Plus Tablet.
  • Can this medicine be taken during pregnancy?
    Macox Plus Tablet is not recommended for use if you are pregnant. It may cause harm to your foetus; hence, consult your doctor before using it.
  • Can this medicine be taken while breast-feeding?
    Macox Plus Tablet passes into breastmilk. Thus, it is not recommended for use if you are breastfeeding.

Allergy

If you have a known allergy to Macox Plus Tablet, avoid this medication. Seek immediate medical attention if you notice any symptoms of allergic reactions such as a skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Antiviral medications

Macox Plus Tablet is not recommended for use if you are receiving antiviral therapy. This medicine can decrease the effectiveness of antiviral medicines and may lead to viral resistance.

Severe liver impairment

Macox Plus Tablet should be used with caution if you have any liver conditions. This medicine is metabolised in your liver, and improper liver function can lead to the accumulation of this medicine in your body. This may worsen your condition.
Warnings for special population

Pregnancy

Macox Plus Tablet is not recommended for use if you are pregnant. It may cause harm to your foetus; hence, consult your doctor before using it.

Breast-feeding

Macox Plus Tablet passes into breastmilk. Thus, it is not recommended for use if you are breastfeeding.
General warnings

Kidney impairment

Macox Plus Tablet should be used with caution if you have any medical conditions affecting your kidneys. Any kidney dysfunction can lead to its accumulation of the medicine in your body. This may worsen your condition.

Diabetes

Macox Plus Tablet should be used with caution if you have diabetes (a condition in which the blood sugar level increases). This medicine may alter your blood sugar levels and affect the management of diabetes.

Antibiotic-resistance

Usage of Macox Plus Tablet without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of the development of bacteria that are drug-resistant.

Liver enzymes

Macox Plus Tablet may elevate liver enzyme levels. Used it with caution and get your liver function tests done regularly.

Use in children

Macox Plus Tablet is not recommended for use in children below 15 years of age due to the lack of safety and efficacy of its use.

Elderly patients

Macox Plus Tablet should be used with caution in elderly patients.

Missed Dose

If you have missed Macox Plus Tablet dose, make sure that you remember to take the next dose on time. Do not take two doses together to make up for a missed dose.

Overdose

Never take Macox Plus Tablet more than the prescribed dose. If you suspect that you have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid drinking alcohol while on treatment with Macox Plus Tablet as it may increase the risk of side effects such as dizziness, flushing, increased heartbeat, nausea, thirst, etc.
Interaction with Medicine

Clopidogrel

Propranolol

Warfarin

Live cholera vaccine

Diltiazem

Atorvastatin

Disease interactions

Colitis

Macox Plus Tablet should be used with caution if you have colitis [swelling of the colon (a part of the intestine)]. This medication may cause the infection to flare up, thus can worsen your condition.

Hematopoietic disturbances

Hematopoietic disturbances are disorders that primarily affect the blood & blood-forming organs like bone marrow. Take Macox Plus Tablet with extreme caution as it may worsen your condition.

Porphyria

Porphyria is a blood disorder that is caused due to build-up of certain chemicals related to red blood cell proteins. Take Macox Plus Tablet with extreme caution as it may worsen your condition.
Food interactions
Macox Plus Tablet should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal because food decreases the absorption of this medicine.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Macox Plus Tablet on an empty stomach, either 1 hour before or 2 hours after a meal. Do not consume in larger or smaller amounts than advised. Consult your doctor if you experience any undesirable effects. It may cause discolouration (yellow, orange, red, brown) of your teeth, urine, sweat, sputum, and tears. Soft contact lenses may be permanently stained. This is normal and not harmful. This medicine may reduce the effects of oral contraceptives (medicines to prevent an unwanted pregnancy). Thus, use effective preventive measures to prevent unwanted pregnancy. You may be advised to take Vitamin B6 when you are prescribed Macox Plus Tablet.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Macox Plus Tablet is a combination of two medicines, Rifampicin and Isoniazid. Rifampicin acts by blocking the action of a bacterial component, which is necessary for tuberculosis bacteria to multiply. Isoniazid prevents the growth of the protective layer of these bacteria. They work together to kill the bacteria and treat the infection.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antituberculosis combinations

Schedule

Schedule H

Drugs, H., 2021. Isoniazid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 31 August 2021].

https://medlineplus.gov/druginfo/meds/a682401.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Isoniazid. [online] Available at: < [Accessed 31 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/3767>

Dailymed.nlm.nih.gov. 2021. RIFAMATE® (rifampin and isoniazid capsules USP). [online] Available at: < [Accessed 31 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc36609-8e2d-4caa-a8e0-c0367e3e52df>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 24 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050420s073,050627s012lbl.pdf>

Drugs, H., 2021. Rifampin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 31 August 2021].

https://medlineplus.gov/druginfo/meds/a682403.html>
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Information on this page was last updated on 9 Sep 2021

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.