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Macox Plus-150 Tablet
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Macox Plus-150 Tablet

Manufactured byMACLEODS PHARMACEUTICALS PVT LTD
ContainsRifampicin (150 mg) + Isoniazid (100 mg)
Description
Macox Plus-150 Tablet is a combination medicine which may be used for the treatment of tuberculosis. It is important to continue treatment with this medicine even if you feel better; do not stop the use of this medicine without consulting your doctor.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Macox Plus-150 Tablet

  • Abdominal pain
  • Dizziness
  • Yellow colored eyes or skin
  • Skin rash
  • Dark urine
  • Loss of appetite
  • Nausea or vomiting
  • Unusual tiredness or weakness
  • Tingling or numbness of the hands and feet
  • Convulsions (seizures)
  • Depression
  • Joint pain
  • Unusual bleeding or bruising

Uses of Macox Plus-150 Tablet

What is it prescribed for?

  • Tuberculosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2-4 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to isoniazid, rifampicin, or any other inactive ingredients present in the formulation.

Severe Hepatic impairment

This medicine is not recommended for use in patients suffering from a severe hepatic impairment or an acute liver disease due to the increased risk of worsening of the patient's condition.

Antiviral medications

This medicine is not recommended for use in patients receiving antiviral therapy since it may reduce the effects of antiviral medications and may lead to the development of viral resistance.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Liver enzymes

Use of this medicine may elevate liver enzyme levels in some patients. Close monitoring of liver enzyme levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Skin Reactions

Use of this medicine may cause severe skin reactions including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in some patients. Report any skin rashes or mucosal lesions to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Azole antifungal agents

Protease inhibiors

Warfarin

Amodiaquine

Paracetamol

Atorvastatin

Disease interactions

Gastrointestinal Diseases

This medicine should be used with caution in patients with a history of gastrointestinal diseases, particularly colitis due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Porphyria

This medicine should be used with caution in patients with a history of porphyria due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition.

Peripheral Neuropathy

This medicine should be used with caution in patients with a known history of peripheral neuropathy due to the increased risk of worsening of the patient's condition. Appropriate corrective measures including vitamin B6 supplementation, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with a history of diabetes since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine is not recommended for use in patients with acute liver disease or a known history of liver injury due to the use of this medicine. It should be used with caution in patients with a history of liver diseases due to the increased risk of serious liver injuries which may be fatal. Close monitoring of liver function tests is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
This medicine should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal since food decreases the absorption of this medicine.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine on an empty stomach, either 30 minutes before or 2 hours after a meal. The absorption of this medicine may be reduced if it is taken along with food. Do not consume in larger or smaller amounts than advised. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by interfering with certain processes that help the bacteria to grow and increase in number; this ultimately leads to the death of the bacteria.
Legal Status

Unknown

Unknown

Unknown

Approved

Classification

Category

Antituberculosis combinations

Schedule

Schedule H1

Isoniazid - DrugBank [Internet]. Drugbank.ca. 2018 [cited 15 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB00951

[Internet]. 2017 [cited 29 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21221

Rifampicin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB01045

Isoniazid [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3767#

Rifinah 150mg/100mg Tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 25 April 2019]. Available from:

https://www.medicines.org.uk/emc/product/6123/smpc#
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Information on this page was last updated on 18 Jul 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.