Lurasidone

Description

Lurasidone is an antipsychotic medicine used for the treatment of schizophrenia and bipolar depression. For the treatment of schizophrenia, this medicine is not recommended for use in patients less than 13 years of age. For the treatment of bipolar depression, this medicine is not recommended for use in patients less than 10 years of age. It is not recommended for use in elderly patients suffering from dementia-related psychosis due to the increased risk of death.

Side effects

Major & minor side effects for Lurasidone

  • Difficulty with swallowing
  • Slurred speech
  • Stiffness of arms and legs
  • Blurred vision
  • Chest pain or discomfort
  • Headache
  • Unusual tiredness or weakness
  • Loss of appetite
  • Cough

Uses of Lurasidone

What is it prescribed for?

  • Schizophrenia
  • Bipolar Depression
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 1 to 3 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with known allergy to lurasidone or any other inactive ingredients present along with it.

Strong CYP3A4 inhibitors

This medicine is not recommended for use in patients receiving therapy with strong CYP3A4 inhibitors such as ketoconazole, clarithromycin, voriconazole, etc. due to the increased risk of serious adverse effects.

Strong CYP3A4 Inducers

This medicine is not recommended for use in patients receiving therapy with strong CYP3A4 inducers such as rifampin, phenytoin, carbamazepine, etc. due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Suicidal ideation

This medicine may increase the risk of suicidal thoughts in some patients. Patients should be monitored closely for any changes in behavior or mood. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Tardive dyskinesia

This medicine may cause tardive dyskinesia in some patients. This may result in symptoms such as involuntary movements of the tongue, lips, and face. Patients should be monitored closely for any such symptoms. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Elevated blood glucose levels

This medicine should be used with caution due to the increased risk of elevated blood glucose levels. This risk is especially higher in patients with a history of diabetes mellitus. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in pediatrics

For the treatment of schizophrenia, this medicine is not recommended for use in patients less than 13 years of age. For the treatment of bipolar depression, this medicine is not recommended for use in patients less than 10 years of age.

Prolonged QT interval

This medicine should be used with caution in patients with a known history of prolonged QT intervals due to the increased risk of worsening of the patient's condition. Report any unusual symptoms such as difficulty breathing, changes in heart rate, etc. to the doctor immediately. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Driving or Operating machinery

Use of this medicine may cause symptoms such as blurred vision, dizziness, sleepiness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Atazanavir

Bupropion

Fluconazole

Codeine

Erythromycin

Disease interactions

Seizures

This medicine should be used with caution in patients with a known history of seizure disorder due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes due to the increased risk of elevated blood glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Dementia

This medicine is not recommended for use in patients suffering from dementia-related psychosis due to the increased risk of worsening of the patient's condition as well as death. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Neuroleptic Malignant Syndrome (NMS)

This medicine is not recommended for use in patients with a known history of a neuroleptic malignant syndrome (NMS) due to the increased risk of worsening of the patient's condition including a recurrence of NMS. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as seizures, Parkinson-like symptoms, heat intolerance, high cholesterol levels, etc.
Lab interactions
Information not available.
Take this medicine with food (at least 350 calories). Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts on certain natural chemicals in the brain to bring about a change in the patient's behavior and thinking.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Atypical antipsychotics

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 26 July 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/200603lbls10s11.pdf

[Internet]. Latuda.com. 2018 [cited 26 July 2018]. Available from:

http://www.latuda.com/LatudaPrescribingInformation.pdf

DailyMed - Lurasidone hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 26 July 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=88a244d1-eddb-499c-bee2-e1f49056e78f#

Latuda 18.5mg film-coated tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 26 July 2018]. Available from:

https://www.medicines.org.uk/emc/product/3299/smpc#

Lurasidone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 26 July 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a611016.html

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Information on this page was last updated on 1 Aug 2018

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.