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Lupiflex 4 Tablet
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Lupiflex 4 Tablet

Manufactured byLUPIN LTD
ContainsThiocolchicoside (4 mg) + Ketoprofen (50 mg)
Description
Lupiflex 4 Tablet is a combination medicine used for the treatment of acute low back pain and other painful and inflammatory musculoskeletal conditions in adult patients.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Lupiflex 4 Tablet

  • Itching and skin rash
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Fainting and drowsiness
  • Nausea and Vomiting
  • Diarrhea
  • Yellowing of skin and eyes
  • Photosensitivity
  • Dry mouth
  • Indigestion
  • Dizziness
  • Headache
  • Abdominal pain
  • Mouth sores
  • Nervousness
  • Ringing in ears
  • Difficult or painful urination

Uses of Lupiflex 4 Tablet

What is it prescribed for?

  • Acute low back pain
  • Acute musculoskeletal pain and inflammation
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The time until which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women. Contact your doctor immediately if you suspect a pregnancy while taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women since the risk of adverse effects on the nursing infant is significantly high.

Allergy

This medicine is not recommended for use in patients with a known allergy to ketoprofen, any other NSAIDs, thiocolchicoside, or any other inactive ingredient present along with these medicines.

Severe heart failure

This medicine is not recommended for use in patients with severe heart failure since it may worsen the patient's condition.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe hepatic impairment due to the increased risk of serious adverse effects.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment due to the increased risk of serious adverse effects.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for use in patients planning to undergo a coronary artery bypass graft surgery or patients with a recent heart surgery due to the increased risk of severe adverse reactions.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women. Contact your doctor immediately if you suspect a pregnancy while taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women since the risk of adverse effects on the nursing infant is significantly high.
General warnings

Other medicines

Report the use of all your current medicines including herbs and supplements to the doctor to avoid the chances of a possible interaction with this medicine.

Kidney disease

This medicine should be used with extreme caution in patients with an impaired kidney function due to an increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. Use is not recommended if the impairment is severe.

Driving or Operating machinery

Use of this medicine may cause symptoms such as drowsiness, impaired judgment, and impaired body movements. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

Use in children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Use in women of childbearing potential

Women of childbearing potential should adopt appropriate means of contraception to avoid pregnancies during treatment with this medicine.

Impairment of fertility

Use of this medicine may cause an impairment of fertility in men and women. Discuss all the risks and benefits with your doctor before taking this medicine.

Heart disease

This medicine should be used with caution in patients with heart diseases due to the increased risk of severe adverse effects on the heart, especially after a prolonged use. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperkalemia

This medicine may increase the potassium levels in the blood (hyperkalemia). Report any unusual symptoms to the doctor immediately. Close monitoring of potassium levels may be necessary for some patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypertension

This medicine should be used with caution in patients with a known history of hypertension due to the increased risk of worsening of the patient's condition. Close monitoring of blood pressure is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Gastro-intestinal bleeding

This medicine may cause severe gastrointestinal bleeding and perforation after a prolonged usage. These adverse events may occur with or without warning symptoms. This risk is especially higher in the elderly population and in patients with a history of gastrointestinal diseases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Visual disturbances

This medicine may cause visual disturbances in some patients. Discontinue the use of this medicine in case of any visual disturbances and contact your doctor immediately.

Elderly population

This medicine should be used with caution in the elderly population due to the increased risk of severe adverse effects. These patients should be started at lower doses to check for tolerance. Close monitoring of renal and liver function may be necessary for such patients based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, etc.
Interaction with Medicine

Warfarin

Ketorolac

Prednisolone

ACE inhibitors

Disease interactions

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-induced asthma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.

Anemia

This medicine should be used with caution in patients with a known history of anemia due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Skin Rash

This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Gastro-Intestinal toxicity

This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart attack and Stroke

This medicine may cause a heart attack, stroke, or other associated symptoms after a prolonged use. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function is recommended for such patients. Report any symptoms such as a chest pain, shallow breathing, speech slurring, weakness, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Fluid Retention and edema

This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Do not take this medicine for longer durations than recommended. Report any unusual symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken after food

To be taken as instructed by doctor

May cause sleepiness

How it works
Thiocolchicoside works by interacting with certain specific receptors in the central nervous system to prevent muscle contractions and relieve muscle spasms. Ketoprofen works by blocking the formation of certain chemical substances in the body which are responsible for causing pain and swelling. Their combination is thus better effective in relieving pain and inflammation.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Muscle relaxants

Schedule

Schedule H

[Internet]. 2017 [cited 15 September 2017]. Available from:

https://pdfs.semanticscholar.org/6848/43f3f7ad8f393bd283e514563a8a0e8141f1.pdf

Thiocolchicoside - DrugBank [Internet]. Drugbank.ca. 2017 [cited 15 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB11582

[Internet]. 2017 [cited 15 September 2017]. Available from:

https://iasispharma.com/wp-content/uploads/pdf/RELIEF_PIL_ENG.pdf

[Internet]. 2017 [cited 18 October 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019816s011lbl.pdf

Ketoprofen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 18 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a686014.html

Ketoprofen - DrugBank [Internet]. Drugbank.ca. 2017 [cited 18 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB01009
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Information on this page was last updated on 9 May 2018

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