Lumefantrine

Description

Lumefantrine is an anti-malarial agent used along with artemether for the treatment of an acute, uncomplicated malaria caused by Plasmodium falciparum. This medicine is not recommended for use in patients with a severe or complicated malaria.

Side effects

Major & minor side effects for Lumefantrine

  • Abdominal pain
  • Vomiting
  • Constipation
  • Diarrhea
  • Nausea
  • Itching
  • Rash
  • Hives

Uses of Lumefantrine

What is it prescribed for?

  • Acute uncomplicated malaria
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to lumefantrine or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

QT Prolongation

This medicine should be used with extreme caution in patients suffering from QT prolongation due to the increased risk of worsening of the patient condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Doxorubicin

Doxepin

Azithromycin

Citalopram

Duloxetine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with food, as directed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by interfering with the formation of certain vital substances in the cell of the malarial parasite. This leads to the eventual death of the malaria parasite.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Antimalarial agents

Schedule

Schedule H

Lumefantrine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB06708

Lumefantrine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 10 April 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Benflumetol#section=Odor

[Internet]. Pharma.us.novartis.com. 2018 [cited 10 April 2018]. Available from:

https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/coartem.pdf

[Internet]. Davisplus.fadavis.com. 2018 [cited 10 April 2018]. Available from:

https://davisplus.fadavis.com/3976/meddeck/pdf/artemetherlumefantrine.pdf

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Information on this page was last updated on 18 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.