Lumateperone

Description

Lumateperone is an atypical antipsychotic used for the treatment of schizophrenia in adults. Schizophrenia is a brain disorder characterized by delusions, hallucinations, and reduced speaking. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Lumateperone

  • Drowsiness
  • Nausea
  • Dry mouth
  • Dizziness
  • Weight gain
  • Unsteadiness
  • Skin rash, hives, or itching

Uses of Lumateperone

What is it prescribed for?

  • Schizophrenia
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Lumateperone or any other inactive ingredient present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Tardive dyskinesia

This medicine should be used with extreme caution in patients with tardive dyskinesia, a condition of involuntary repetitive body movements, since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate patient/caregiver education, close monitoring of the patient's condition, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in elderly population

This medicine should be used with extreme caution in the elderly population due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Seizures

This medicine should be used with caution in patients with seizure disorders or central nervous system abnormalities due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Neuroleptic Malignant Syndrome (NMS)

This medicine should be used with extreme caution in patients with a known history of a neuroleptic malignant syndrome (NMS) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or operating machinery

This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.

Weight gain

This medicine is likely to cause a gain in weight and hence periodic monitoring is required especially in patients who are obese.

Lipid alterations

This medicine may alter lipid levels in the body. Report any unusual symptoms to the doctor immediately. Close monitoring of lipid levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus because it may alter the blood glucose levels in such patients. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Orthostatic hypotension

This medicine is likely to cause a position based decrease in blood pressure especially during the start of therapy. It should be given very carefully to patients who have an active disease of the heart and valves. Any condition leading to a decrease in blood pressure should be given consideration while deciding the dose.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Ciprofloxacin

Bupropion

Pioglitazone

Diltiazem

Rifampicin

Disease interactions

Dementia

This medicine is not recommended for use in patients with dementia-related psychosis due to the increased risk of heart failure, pneumonia, death, etc. This risk is especially high in elderly patients. Replacement with a suitable alternative should be considered under your doctor's supervision.
Food interactions
Consumption of grapefruit and grapefruit juice during treatment with this medicine is not recommended due to the risk of severe side effects.
Lab interactions
Information not available.
Take this medicine exactly advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine before completion of the course/without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by binding to the receptors and inhibits release of the chemical substances that cause psychotic symptoms.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Atypical antipsychotics

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2020 [cited 4 May 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209500s000lbl.pdf

Lumateperone [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 4 May 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Lumateperone

Lumateperone - DrugBank [Internet]. Drugbank.ca. 2020 [cited 4 May 2020]. Available from:

https://www.drugbank.ca/drugs/DB06077

Lumateperone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 13 May 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a620014.html

DailyMed - Caplyta - lumateperone capsule [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 13 May 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=db730b06-6351-47fd-8183-e61e61bbead5

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Information on this page was last updated on 13 May 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.