Loxapine

Description

Loxapine is an antipsychotic medication used in the treatment of schizophrenia. This medicine should be taken at the same time regularly. This medicine is not indicated for use in children.

Side effects

Major & minor side effects for Loxapine

  • Difficulty in speaking (dysphonia) and swallowing
  • Loss of balance control
  • Shuffling walk
  • Stiffness of arms and legs
  • Constipation
  • Difficulty urination
  • Skin Rash
  • Muscle cramps
  • Blurred vision
  • Confusion
  • Dry mouth and lips
  • Drowsiness

Uses of Loxapine

What is it prescribed for?

  • Schizophrenia
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Concerns

Commonly asked questions

  • Onset of action
    The time required for this medicine to show its action is about 20 to 30 minutes.
  • Duration of effect
    This medicine remains active in the body for about 12 hours after administration.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of drowsiness, dizziness, impaired judgment, and difficulty in concentration. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Severe central nervous system disorders

This medicine is not recommended for use in patients with severe central nervous system depression, coma, or uncontrolled seizures disorder due to the increased risk of worsening of the patient's condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to loxapine or any other ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Dementia- related psychosis

Loxapine is not approved for use in patients with dementia-related psychosis due to the increased risk of death.

Neuroleptic Malignant Syndrome

Loxapine should be discontinued immediately if the patient develops Neuroleptic Malignant Syndrome, a condition characterized by an increase in the body temperature, muscle rigidity, and altered consciousness.

Tardive dyskinesia

Loxapine may cause involuntary movements of the tongue, lips, and face. Report any such symptoms to the doctor immediately. Gradual dose reduction or discontinuation of the medicine may be required based on the clinical condition.

Seizures

Loxapine should be used with caution in patients with a known history of seizure disorder due to the increased risk of recurrent seizures. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Drowsiness

Loxapine may cause drowsiness. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heaving machinery during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of drowsiness, dizziness, impaired judgment, and difficulty in concentration. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Clozapine

Tramadol

Zonisamide

Fentanyl

Methadone

Pentazocine

Disease interactions

Dementia

This medicine is not recommended for use in patients with dementia-related psychosis due to the increased risk of death. An alternate medicine should be considered based on the clinical condition.

Parkinsonism

This medicine is not recommended for use in patients with Parkinson's disease due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver Disease

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of severe side effects. Appropropriate dose adjustments should be considered based on the clinical condition of the patient.

CNS Depression

This medicine should be used with extreme caution in patients with a known history of CNS depression due to the increased risk of serious adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Intestinal obstruction

This medicine should be used with caution in patients with a known history of intestinal obstruction due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with a known history of glaucoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Loxapine as instructed by your doctor. Do not take in larger or smaller amounts than advised. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It reduces the symptoms of schizophrenia such as loss of interest in life, emotional distress, etc.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Miscellaneous antipsychotic agents

Schedule

Schedule H

DailyMed - Loxapine succinate tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dee2537b-1bd8-42f6-990f-62359e646822

Loxapine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 24 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00408

Loxapine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 24 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682311.html

[Internet]. 2017 [cited 8 September 2017]. Available from:

http://www.psychatlanta.com/psychatlanta/wp-content/uploads/loxitane.pdf

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Information on this page was last updated on 9 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.