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Losartas-A (5/50 mg) Tablet
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Losartas-A (5/50 mg) Tablet

Manufactured byIntas Pharmaceuticals Ltd.
ContainsAmlodipine (5 mg) + Losartan (50 mg)
Description
Losartas-A (5/50 mg) Tablet is a combination of Amlodipine and Losartan. It is an anti-hypertensive medicine used for the treatment of high blood pressure. Losartas-A (5/50 mg) Tablet relaxes the heart muscles and widens the blood vessels, which decreases blood pressure and makes it easier for your heart to pump blood throughout your body. Losartas-A (5/50 mg) Tablet shows common side effects like headache, drowsiness, dizziness, swelling of feet and ankles, tiredness and stomach upset. Most of these side effects do not require medical attention and disappear with time. If these symptoms worsen, consult your doctor. Losartas-A (5/50 mg) Tablet can be taken with or without food. Your doctor will decide the dosage based on your clinical condition. Do not self-medicate or stop taking it without your doctor's recommendation as it can lead to withdrawal symptoms. Be careful while standing up from a sitting or lying down position as Losartas-A (5/50 mg) Tablet may sometimes cause dizziness. Avoid taking Losartas-A (5/50 mg) Tablet with alcohol and grapefruit juice as it can cause dizziness. Losartas-A (5/50 mg) Tablet is not recommended if you have liver and kidney problems or have high potassium levels in your blood. Losartas-A (5/50 mg) Tablet is not recommended in children below 6 years, pregnant women and breastfeeding women unless prescribed by your doctor.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Losartas-A (5/50 mg) Tablet

  • Stomach pain
  • Chills
  • Difficult or painful urination
  • Back pain
  • Chest tightness
  • Weakness in arms, hands, legs or feet
  • Swelling of ankles or feet
  • Difficulty in breathing
  • Dizziness
  • Increased heartbeat
  • Redness of face, neck, arms and chest
  • Taste alterations
  • Stomach upset
  • Cough
  • Headache
  • Sleepiness

Uses of Losartas-A (5/50 mg) Tablet

What is it prescribed for?

  • Essential hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    After taking Losartas-A (5/50 mg) Tablet, the blood pressure will gradually decrease in 4-8 hours.
  • How long do the effects of this medicine last?
    Losartas-A (5/50 mg) Tablet on average can be effective for up to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol during treatment with Losartas-A (5/50 mg) Tablet. Do not perform activities that require high mental alertness such as driving vehicles or operating machines if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    Losartas-A (5/50 mg) Tablet has no habit-forming tendencies.
  • Can this medicine be taken during pregnancy?
    Avoid Losartas-A (5/50 mg) Tablet in pregnancy as it may affect your developing foetus. If you are pregnant or planning a pregnancy, consult your doctor.
  • Can this medicine be taken while breast-feeding?
    It is not known whether Losartas-A (5/50 mg) Tablet passes into the breastmilk. This medicine may probably be safe to be used during breastfeeding. However, inform your doctor if you are breastfeeding while taking this medicine.

Allergy

Avoid taking Losartas-A (5/50 mg) Tablet if you are allergic to it or any of the ingredients present in this medicine. Seek medical attention if you notice symptoms such as skin rash, hives (painful eruptions that itch and sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc.
Warnings for special population

Pregnancy

Avoid Losartas-A (5/50 mg) Tablet in pregnancy as it may affect your developing foetus. If you are pregnant or planning a pregnancy, consult your doctor.

Breast-feeding

It is not known whether Losartas-A (5/50 mg) Tablet passes into the breastmilk. This medicine may probably be safe to be used during breastfeeding. However, inform your doctor if you are breastfeeding while taking this medicine.
General warnings

Hyperkalaemia

Losartas-A (5/50 mg) Tablet may increase the potassium levels (hyperkalaemia) in the body by preventing the excretion of potassium from the kidneys. Avoid potassium-rich foods or supplements while you are on this medication. Your doctor will suggest tests to regularly monitor your potassium levels. Your doctor may also adjust the dose of this medicine based on your clinical condition.

Use in children

Losartas-A (5/50 mg) Tablet is not recommended for use in children below 6 years of age since the safety and efficacy data of the use of this medicine in that group are not clinically established.

Liver disease

Use Losartas-A (5/50 mg) Tablet with caution if you have liver problems. Losartas-A (5/50 mg) Tablet is broken down in your liver. Having liver problems may increase the accumulation of this medicine in your body which may damage your liver further. Your doctor will suggest tests to regularly monitor your liver function. He may also adjust the dose of the medicine as per requirements.

Aortic stenosis

Aortic Stenosis is the narrowing of the valve of the aorta (the largest blood vessel that branches off from your heart). Losartas-A (5/50 mg) Tablet should be used with extreme caution if you have aortic stenosis due to the increased risk of hypotension (low blood pressure). It is recommended that you regularly monitor your blood pressure while taking this medicine. Your doctor may adjust the dose of the medicine as per requirements.

Driving and operating machines

Losartas-A (5/50 mg) Tablet may cause dizziness or drowsiness in some people. Avoid performing activities that require mental alertness like driving vehicles or operating machines if you experience any of these symptoms while taking this medicine.

Renal Impairment

Losartas-A (5/50 mg) Tablet should be used carefully if you have kidney problems like renal artery stenosis (narrowing of the arteries that carry blood to the kidneys) and/or volume depletion (excess loss of salt and fluid leading to reduced fluid volume). Your doctor will suggest tests to regularly monitor your kidney function while taking this medicine in such conditions.

Missed Dose

If you forget to take your medicine, take the missed dose of Losartas-A (5/50 mg) Tablet as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume at the scheduled time. Do not double your dose to make up for the missed one.

Overdose

Never take more than the dose prescribed by your doctor. If you have accidentally taken an overdose of Losartas-A (5/50 mg) Tablet, contact your doctor immediately for an overdose treatment.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol during treatment with Losartas-A (5/50 mg) Tablet. Do not perform activities that require high mental alertness such as driving vehicles or operating machines if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Carbamazepine

Itraconazole

Lithium

Prednisolone

Rifampicin

Aliskiren

NSAIDs

Disease interactions

Congestive heart failure

Congestive heart failure occurs when your heart muscle is not able to pump blood normally. Losartas-A (5/50 mg) Tablet should be used with caution if you have congestive heart failure as it may increase the risk of severe hypotension (low blood pressure) and acute kidney damage. It is recommended that you regularly monitor your blood pressure while you are taking this medicine. Your doctor will suggest tests to monitor your kidney function while on treatment with this medicine.

Severe hypotension or cardiogenic shock

Losartas-A (5/50 mg) Tablet should be taken with caution in conditions like cardiogenic shock (a life-threatening condition where the heart suddenly stops pumping blood to the body) or if you have severe hypotension (low blood pressure) due to increased risk of heart failure. It is recommended that you closely monitor your blood pressure. Your doctor may adjust the dose of the medicine depending on your clinical condition.
Food interactions
Grapefruit juice may decrease the effect of Losartas-A (5/50 mg) Tablet. Hence avoid consuming grapefruit juice while taking this medicine.
Avoid taking high potassium containing food or potassium supplements with Losartas-A (5/50 mg) Tablet as it may cause an increase in the potassium levels in your blood. Consult your doctor if you have symptoms such as weakness, irregular heartbeat, confusion, tingling sensation or feeling of heaviness in the legs.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Losartas-A (5/50 mg) Tablet orally with or without food. Do not crush, break or chew the tablet. Take it at the same time every day. Avoid taking more or less dose than that prescribed by your doctor. Keep taking the medicine regularly even if your condition improves. Do not self-medicate or stop the medication without your doctor's advice. Lifestyle modification is also essential in improving your condition, hence you should eat a balanced diet and exercise regularly to get the maximum benefit from the treatment. Avoid taking grapefruit juice with Losartas-A (5/50 mg) Tablet as it may decrease the effect of this medicine. As Losartas-A (5/50 mg) Tablet may increase the potassium level in the blood, avoid potassium-rich food or potassium supplements unless advised by your doctor. Losartas-A (5/50 mg) Tablet may make you feel dizzy or lightheaded, so be careful when standing up suddenly. It can cause sleepiness and dizziness, so avoid driving or operating machines unless you know how this medicine affects you. Losartas-A (5/50 mg) Tablet may cause swelling of the ankles which can be avoided by low salt intake and keeping your leg raised when you are sitting down.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Losartas-A (5/50 mg) Tablet is a combination of Amlodipine and Losartan. Amlodipine and Losartan widens the blood vessels by relaxing the heart muscles and helps in the smooth flow of blood. This combination causes a decrease in blood pressure and reduces strain on the heart.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Angiotensin II inhibitors with calcium channel blockers

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 24 June 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s047lbl.pdf>
Abernethy, D., 1992. Pharmacokinetics and Pharmacodynamics of Amlodipine. Cardiology, 80(1), pp.31-36.

Mri.cts-mrp.eu. 2021. [online] Available at: < [Accessed 24 June 2021].

http://mri.cts-mrp.eu/download/HU_H_0350_001_PAR.pdf>

Lupin.com. 2021. [online] Available at: < [Accessed 24 June 2021].

https://www.lupin.com/US/pdf/12/Patient%20Information%20Leaflet-running%20text.pdf>

Medicines.org.uk. 2021. Losartan potassium 50 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 24 June 2021].

https://www.medicines.org.uk/emc/product/7061/smpc>

Medicines.org.uk. 2021. Amlodipine 5mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 3 August 2021].

https://www.medicines.org.uk/emc/product/4717/smpc#gref>
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Information on this page was last updated on 9 Sep 2021

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