Loperamide

Description

Loperamide is a very effective anti-diarrhea medication. It is used to relieve the symptoms of diarrhea that starts suddenly and lasts for a few days. It is also used to treat long-term diarrhea associated with other diseases.

Side effects

Major & minor side effects for Loperamide

  • Bloating
  • Constipation
  • Loss of appetite
  • Severe stomach ache
  • Paralytic ileus
  • Allergic skin reaction
  • Dizziness
  • Dry mouth

Uses of Loperamide

What is it prescribed for?

  • Acute diarrhea
  • Chronic diarrhea
  • Traveler's Diarrhea
  • Ileostomy
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-3 hours of administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 40 hours.
  • Safe with alcohol?
    Use of alcohol should be avoided or restricted while you are taking this medicine. Activities requiring a high level of mental alertness should be avoided at least in the initial part of treatment with this medicine.
  • Is it habit forming?
    Some habit forming tendencies were reported when large doses of this medicine were consumed without prescription.
  • Usage in pregnancy?
    Use of this medicine is not recommended for pregnant women unless the potential benefits outweigh the risk associated with use. Consult your doctor before taking this medicine.
  • Usage while breast-feeding?
    Use of this medicine is not recommended while breastfeeding an infant. If it becomes absolutely necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor before taking this medicine.

Allergy

This medicine is not recommended for use if you have a known history of allergy to Loperamide (the primary constituent of Loperamide).

Abdominal pain

This medicine is not recommended for use if you have stomach pain without loose stools.

Acute colitis

This medicine is not recommended for use in patients suffering from an infected colon or infectious diarrhea/dysentery. Symptoms may include bloody stools and high fever. The infection could be caused by Clostridium, Salmonella, Shigella or Campylobacter strains of bacteria.

Antibiotic induced diarrhea

This medicine is not recommended for use if you have an episode of diarrhea caused by consumption of an antibiotic.
Warnings for special population

Pregnancy

Use of this medicine is not recommended for pregnant women unless the potential benefits outweigh the risk associated with use. Consult your doctor before taking this medicine.

Breast-feeding

Use of this medicine is not recommended while breastfeeding an infant. If it becomes absolutely necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor before taking this medicine.
General warnings

Dizziness

Use of this medicine may cause drowsiness and dizziness which may impair physical activities.

Hypersensitivity

Use of this medicine may cause allergic reactions of the skin in some patients. Some cases of severe allergic conditions like Steven's Johnson Sundrome or Toxic epidermal necrolysis have been reported with the use of this medicine.

No symptomatic improvement

Use of this medicine should be discontinued if the symptoms do not improve within 48 hours in patients with acute diarrhea.

Liver disease

This medicine should be used with caution in patients with liver function impairment.

Heart conditions

Use of this medicine in large quantities may cause a severe adverse effect on the heart and blood vessels. Non-prescription use of this medicine must be avoided.

Other medicines

Report the current use of all medicines including supplements and herbs to the doctor as this medicine is known to interact with other medicines that you might be possibly consuming. Use of medicines to treat heart conditions and infections should be informed to the doctor before taking this medicine.

Infectious diarrhea

Use of this medicine is not recommended for infectious diarrhea characterized by the presence of pus or blood in stools, high fever etc. Acute diarrhea and dysentery caused by bacteria should not be treated with this medicine.

AIDS

This medicine should be used with caution in patients having AIDS and taking antiviral medications.

Pediatric use

This medicine should be used with caution in patients aged below 6 years. Use in children below 2 years of age is not recommended.

Constipation

Use of this medication is not recommended in patients suffering from blockage of intestine and constipation.

Missed Dose

This medicine is not taken in a scheduled way and hence missing a dose is not possible. However, care should be taken to not exceed the daily recommended limit.

Overdose

Contact a doctor immediately if an overdose is suspected. Symptoms of overdose may include dizziness, confusion, severe stomach cramps and pain, constipation etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Use of alcohol while taking this medicine can significantly increase some side effects like dizziness, sleepiness, and difficulty in concentrating. Some people suffer from additional side effects like impaired thinking and judgment.

Instructions

Use of alcohol should be avoided or restricted while you are taking this medicine. Activities requiring a high level of mental alertness should be avoided at least in the initial part of treatment with this medicine.
Interaction with Medicine

Clarithromycin

Ketoconazole

Ranitidine

Quinidine

Ritonavir

Disease interactions

Infectious Diarrhea

This medicine is not recommended for use in patients having infectious diarrhea. The symptoms may worsen and get prolonged if this medicine is used in such cases. Any incidence of diarrhea accompanied by the presence of blood or pus in stools and high fever should be promptly reported to the doctor.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Loperamide as instructed by the doctor. This medicine can be taken with or without food. Do not take more than the prescribed dose or use for longer than recommended. It is recommended to take sufficient fluid while taking this medicine. Contact your doctor if the symptoms do not improve within 48 hours of taking this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by reducing the movement of food and water from the stomach and intestine. The reduced bowel activity makes the food stay longer in the intestine resulting in increased absorption of water and symptoms of diarrhea are relieved.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antidiarrheals

Schedule

Schedule H

[Internet]. 2017 [cited 28 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21097

DailyMed - loperamide hydrochloride capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=871e2a73-a1e9-4952-8cf2-15da430117ce

Loperamide | C29H33ClN2O2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 28 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3955

Loperamide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 28 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682280.html

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.