Lixisenatide
Description
Lixisenatide is used along with diet and exercise to control blood sugar levels in adults with type 2 diabetes mellitus. This medicine is normally used in patients who have not achieved adequate control of blood sugar levels with other oral therapies. It is not used to treat type 1 diabetes mellitus.
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Side effects
Major & minor side effects for Lixisenatide
- Nausea or Vomiting
- Diarrhea
- Constipation
- Dizziness and lightheadedness
- Heartburn
- Headache
- Excessive sweating
- Severe skin rash and hives
Uses of Lixisenatide
What is it prescribed for?
- Type II Diabetes Mellitus
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known history of allergy to Lixisenatide or any other inactive ingredients present along with it.
Severe renal impairment
This medicine is not recommended for use in patients with severe renal impairment (creatinine clearance < 30 mL/min) due to the increased risk of worsening of the patient’s condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings
Other medicines
Lixisenatide may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.
Weight loss
Use of this medicine has been associated with a mild to moderate weight loss. However, it should never be used for this purpose.
Gastroparesis
This medicine is not recommended for use in patients with gastroparesis due to the increased risk of serious adverse effects. An alternative treatment option may be necessary in some cases based on the clinical condition.
Type I diabetes
This medicine is not recommended for use in patients suffering from type 1 diabetes mellitus.
Kidney disease
This medicine should be used with caution in patients with mild to moderate kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients suffering from severe renal impairment.
Angioedema
This medicine may cause anaphylaxis and other hypersensitivity reactions, including angioedema, in some patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Missed Dose
Administer the missed dose as soon as you remember. If you remember the missed dose after you have consumed your meal or if it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
Interaction with Medicine
Insulin
Formoterol
Epinephrine
Ciprofloxacin
Gatifloxacin
Disease interactions
Kidney Disease
This medicine should be used with caution in patients with mild to moderate kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients suffering from severe renal impairment.
Pancreatitis
This medicine should be used with caution and monitoring in patients with pre-existing pancreatitis. Treatment with this medicine should be discontinued immediately if symptoms worsen. An alternative treatment option may be necessary in such cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer this medicine exactly as prescribed by the doctor. Follow all the usage related instructions mentioned in the leaflet or the package insert. This medicine should be injected within 60 minutes before the morning and evening meals. There should be a minimum time gap of 6 hours between the two meals. Do not share the injection or the prefilled syringe. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by stimulating the pancreas to secrete insulin when the blood sugar level in the body is high.
Legal Status
Classification
Category
Incretin mimetics
Schedule
Schedule H
Lyxumia 20 micrograms solution for injection - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 25 September 2018]. Available from:
Lixisenatide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 25 September 2018]. Available from:
[Internet]. Products.sanofi.in. 2019 [cited 1 March 2019]. Available from:
DailyMed - Adlyxin- lixisenatide Adlyxin- lixisenatide injection, solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 1 March 2019]. Available from:
Information on this page was last updated on 1 Mar 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.