Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Cognitive impairment
This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and usually disappear once the medicine is discontinued.
Muscle degradation and Rhabdomyolysis
This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with kidney diseases, hypothyroidism, and active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Driving and operating machines
This medicine may cause symptoms such as blurred vision, dizziness, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Hyperkalemia
This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine.
Liver function impairment
This medicine may cause moderate to severe liver impairment in some patients. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Pediatric population
This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.
Cough
This medicine may cause a persistent nonproductive cough in some patients. It is usually resolved when the medicine is discontinued.
Heart Failure
This medicine may cause heart failure and reduced flow of blood in some patients. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Major surgery
This medicine should be used with extreme caution in patients undergoing a major surgery due to the increased risk of severe adverse effects. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Pheochromocytoma
This medicine should be administered with extreme caution in patients suffering from pheochromocytoma, a condition which results in an excess of a substance that controls heartbeat and blood pressure. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Bronchospastic Disease
This medicine should be administered with extreme caution in patients with a disease of the lung or the airways leading to the lungs such as pneumonia, asthma, or chronic obstructive pulmonary disease. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Altered blood sugar levels
This medicine may cause an alteration in the blood sugar levels. This risk is especially higher in patients with diabetes mellitus. Close monitoring of blood sugar levels may be necessary based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.
Hyperthyroidism
This medicine should be administered with caution in patients suffering from hyperthyroidism since it may mask some of the patient's symptoms. Close monitoring of thyroid hormone levels is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Peripheral Vascular Diseases
This medicine should be used with caution in patients suffering from peripheral vascular diseases since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.