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Lifepill 3 Capsule

Manufactured byZydus Cadila
ContainsAtorvastatin (10 mg) + Metoprolol (25 mg) + Ramipril (5 mg)
Description

Lifepill 3 Capsule is a combination medicine which may be used for the treatment of patients suffering from both high blood pressure and hypercholesterolemia. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients less than 18 years of age.

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Side effects

Major & minor side effects for Lifepill 3 Capsule

  • Blurred vision
  • Increased sweating
  • Dizziness
  • Unusual tiredness and weakness
  • Back pain
  • Chest tightness
  • Cough
  • Diarrhea
  • Irregular heart beat
  • Shortness of breath
  • Nausea and Vomiting
  • Skin rash
  • Difficulty in swallowing
  • Muscle and joint pain
  • Sleep disturbances

Uses of Lifepill 3 Capsule

What is it prescribed for?

  • Essential hypertension with Hypercholesterolemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The antihypertensive effect of this medicine can be observed within 1 to 2 hours. The anti-hypercholesteremic effect of this medicine is cumulative and may take up to 3 to 5 days to show its results.
  • How long do the effects of this medicine last?
    The antihypertensive effect of this medicine lasts for an average duration of 24 hours. The anti-hypercholesteremic effect of this medicine may last for an average duration of 3 to 4 days after the onset of action.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, headache, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to metoprolol, other beta-blockers, atorvastatin, ramipril, other ACE inhibitors, or any other inactive ingredients present along with the formulation.

Aliskiren

Coadministration of aliskiren and this combination of medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Heart diseases

This medicine is not recommended for use in patients with serious heart problems such as a heart block, heart failure, sick sinus syndrome, etc. due to the increased risk of worsening of the patient's condition.

Active liver disease

This medicine is not recommended for use in patients with active liver diseases since it may worsen the patient's condition.

Circulatory Disorders

This medicine is not recommended for use in patients suffering from blood circulation disorders since it may worsen the patient's condition.

Angioedema

This medicine is not recommended for use in patients with a known history of angioedema due to the increased risk of recurrent symptoms.

Renal artery stenosis

This medicine is not recommended for use in patients with a known history of renal artery stenosis due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Cognitive impairment

This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and usually disappear once the medicine is discontinued.

Muscle degradation and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with kidney diseases, hypothyroidism, and active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Driving and operating machines

This medicine may cause symptoms such as blurred vision, dizziness, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine.

Liver function impairment

This medicine may cause moderate to severe liver impairment in some patients. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Pediatric population

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Cough

This medicine may cause a persistent nonproductive cough in some patients. It is usually resolved when the medicine is discontinued.

Heart Failure

This medicine may cause heart failure and reduced flow of blood in some patients. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Major surgery

This medicine should be used with extreme caution in patients undergoing a major surgery due to the increased risk of severe adverse effects. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Pheochromocytoma

This medicine should be administered with extreme caution in patients suffering from pheochromocytoma, a condition which results in an excess of a substance that controls heartbeat and blood pressure. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Bronchospastic Disease

This medicine should be administered with extreme caution in patients with a disease of the lung or the airways leading to the lungs such as pneumonia, asthma, or chronic obstructive pulmonary disease. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Altered blood sugar levels

This medicine may cause an alteration in the blood sugar levels. This risk is especially higher in patients with diabetes mellitus. Close monitoring of blood sugar levels may be necessary based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Hyperthyroidism

This medicine should be administered with caution in patients suffering from hyperthyroidism since it may mask some of the patient's symptoms. Close monitoring of thyroid hormone levels is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Peripheral Vascular Diseases

This medicine should be used with caution in patients suffering from peripheral vascular diseases since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, headache, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Corticosteroids

Atazanavir

Aliskiren

Insulin

Ergotamine

Nonsteroidal anti-inflammatory medicines

Amlodipine

Azithromycin

Angiotensin Receptor Blockers (ARB)

Erythromycin

Aminophylline

Diltiazem

Cyclosporine

Disease interactions

Angioedema

This medicine is not recommended for use in patients with a history of angioedema or a family history of angioedema due to the increased risk of recurrent symptoms. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Bone marrow suppression

This medicine should be used with caution in patients with bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of complete blood count is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Respiratory Diseases

This medicine is not recommended for use in patients with respiratory diseases such as bronchial asthma or chronic obstructive pulmonary disease due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Heart Block

This medicine is not recommended for use in patients with a heart block greater than the first degree unless a permanent pacemaker is present. Replacement with a suitable alternative should be considered under your doctor's supervision.

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver Disease

This medicine is not recommended for use in patients with active liver diseases. In patients with liver impairment, this medicine should be used with extreme caution due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Glaucoma

This medicine should be administered with caution in patients suffering from glaucoma. A change in the dose of the current glaucoma medicine may be required in some cases. Replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of adverse effects such as dizziness, muscle pain, fever and chills, headache, swelling of hands and feet, vomiting, skin rash, etc.
It is recommended to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects. Your doctor/dietitian will suggest an appropriate diet for you to avoid high intake of potassium.
Coadministration of multivitamin with minerals and this combination medicine may decrease the effects of this medicine. Close monitoring of blood pressure and appropriate dose adjustments may be necessary in some cases based on the clinical condition. Your doctor may advise you to maintain an appropriate time gap between the consumption of multivitamin with minerals and this medicine to minimize their interaction.
Lab interactions
Information not available.
Take this medicine as instructed by the doctor. It is advised to take this medicine preferably at the same time every day. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Metoprolol relaxes the blood vessels and reduces the heart rate. Atorvastatin reduces the level of cholesterol in the blood. Ramipril relaxes the blood vessels and promotes the smooth flow of blood. Their combination is thus helpful in treating both hypercholesterolemia and high blood pressure.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Cardioselective beta blockers, Statins, Angiotensin converting enzyme inhibitors

Schedule

Schedule H

[Internet]. Dailymed.nlm.nih.gov. 2019 [cited 23 April 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b59207a-ea5c-4697-a8b6-94c3015a00de

Metoprolol Tartrate Tablets BP 50mg - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 15 May 2018]. Available from:

https://www.medicines.org.uk/emc/product/5816/smpc

Atorvastatin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 6 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a600045.html

Metoprolol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 15 May 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682864.html
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Information on this page was last updated on 3 Jul 2019

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