Lenvatinib

Description

Lenvatinib is an anti-cancer agent which is used for the treatment of thyroid cancer in patients who cannot undergo therapy with radioactive iodine. It is also used in combination with everolimus for the treatment of advanced kidney cancer in patients who had previously received therapy with other medication. It is also used to treat liver cancer that is not capable of being surgically removed.

Side effects

Major & minor side effects for Lenvatinib

  • Constipation
  • Nosebleed
  • Fast heartbeat
  • Vomiting
  • Coughing up blood
  • Hair loss
  • Bleeding gums
  • Skin rash
  • Heartburn or indigestion
  • Yellow colored eyes or skin
  • Stomach pain or tenderness
  • Troubled breathing
  • Loss of appetite

Uses of Lenvatinib

What is it prescribed for?

  • Thyroid cancer
  • Advanced Renal Cell Carcinoma (RCC)
  • Hepatocellular carcinoma
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to lenvatinib or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients suffering from stomach or intestine problems due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hypocalcemia

This medicine should be used with caution in patients with hypocalcemia (low blood calcium levels) due to the increased risk of severe adverse effects. Close monitoring of blood calcium levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may cause dizziness, visual disturbances, and tiredness. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

QT interval prolongation

This medicine should be used with extreme caution in patients who have or may develop prolongation of QT interval due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Bleeding

This medicine should be used with extreme caution in patients with a known risk of bleeding due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Heart diseases

This medicine should be used with caution in patients with heart diseases due to the increased risk of worsening of the patient's condition. Close monitoring of the heart function, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ondansetron

Fluconazole

Haloperidol

Amiodarone

Moxifloxacin

Disease interactions

Hypertension

This medicine should be used with caution in patients with increased blood pressure since it may worsen the patient's condition. Appropriate dose adjustments and frequent clinical monitoring are advised. An alternative treatment option should be considered in some cases based on the clinical condition.

Hypothyroidism

This medicine should be used with caution in patients with hypothyroidism (a condition where the thyroid gland does not produce sufficient levels of hormones) due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Lung impairment

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart and blood vessel disorder

This medicine should be used with caution in patients having a disease of the heart or the blood vessels due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is recommended for such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Multikinase inhibitors, VEGF/VEGFR inhibitors

Schedule

Schedule H

[Internet]. Medlineplus.gov. 2019 [cited 22 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a615015.html

[Internet]. Accessdata.fda.gov. 2019 [cited 22 March 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf

[Internet]. Dailymed.nlm.nih.gov. 2019 [cited 22 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4bedd21-efde-44c6-9d9c-b48b78d7ed1e

[Internet]. Drugbank.ca. 2019 [cited 22 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB09078

Kisplyx 10 mg hard capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 23 May 2019]. Available from:

https://www.medicines.org.uk/emc/product/7881/smpc

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Information on this page was last updated on 23 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.