Lenalidomide

Description

Lenalidomide is used in the treatment of myelodysplastic syndrome, a group of blood disorders characterized by immature cells. It is also used in a combination with dexamethasone for the treatment of multiple myeloma, a type of blood cancer. This medicine is not recommended for use in pregnant women as well as in patients less than 18 years of age.

Side effects

Major & minor side effects for Lenalidomide

  • Chest pain
  • Dry mouth
  • Fever
  • Increased thirst
  • Cough
  • Bleeding gums
  • Nausea
  • Sore throat
  • Unusual tiredness or weakness
  • Vomiting

Uses of Lenalidomide

What is it prescribed for?

  • Multiple Myeloma
  • Myelodysplastic syndrome
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of serious adverse effects on the unborn baby.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to lenalidomide or any other inactive ingredients present along with it.

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of harmful effects on the unborn baby.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of serious adverse effects on the unborn baby.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.
General warnings

Renal impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hepatic Failure

This medicine should be used with extreme caution due to the increased risk of liver failure. This risk is especially higher when it is used in a combination with dexamethasone. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Thyroid Disorders

This medicine should be used with caution in patients with hypothyroidism or hyperthyroidism due to the increased risk of worsening of the patient's condition. Regular monitoring of thyroid function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Contraception and sexual intercourse

Female patients of child-bearing potential should always use at least 2 methods of reliable birth control to avoid pregnancy during treatment with this medicine. Contraception must begin at least 4 weeks prior to beginning therapy and continue for at least 4 weeks after discontinuation of therapy. Male patients receiving this medicine should always use a latex or synthetic condom during any sexual contact with females of child-bearing potential while taking this medicine and for up to 28 days after discontinuation of therapy.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Simvastatin

Clozapine

Ethinyl Estradiol

Atorvastatin

Mumps virus Vaccine

Disease interactions

Renal Dysfunction

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Thromboembolism

This medicine should be used with extreme caution in patients with a history of thromboembolism (blood clots) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate preventive measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Anemia

This medicine should be used with caution in patients with a history of anemia, thrombocytopenia (decreased platelet counts), or neutropenia (decreased neutrophil counts) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate preventive and corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger or smaller amounts than advised/prescribed. Your dose is likely to change during the duration of the therapy based on your clinical condition and therapeutic response. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine helps the bone marrow to produce normal blood cells and kills the abnormal cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous antineoplastics, Other immunosuppressants

Schedule

Schedule H

[Internet]. Media.celgene.com. 2018 [cited 1 August 2018]. Available from:

http://media.celgene.com/content/uploads/revlimid-pi.pdf

Lenalidomide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 1 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00480

Lenalidomide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 1 August 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a608001.html

[Internet]. CiplaMed. 2018 [cited 1 August 2018]. Available from:

https://ciplamed.com/content/lenmid-capsules

Revlimid - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 1 August 2018]. Available from:

https://www.medicines.org.uk/emc/product/347

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Information on this page was last updated on 10 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.