Ledipasvir

Description

Ledipasvir is an antiviral medicine used in combination with other medicines for the treatment of chronic hepatitis C infection, genotype 1. This medicine should be used with extreme caution in patients with a known history of hepatitis B infection due to the increased risk of serious adverse reactions.

Side effects

Major & minor side effects for Ledipasvir

  • Blurred vision
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Itching
  • Rash
  • Dry skin
  • Difficulty in falling asleep
  • Irritability
  • Chest pain
  • Fever

Uses of Ledipasvir

What is it prescribed for?

  • Chronic Hepatitis C
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to ledipasvir or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Liver impairment

This medicine should be used with caution in patients with a history of liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hepatitis B

This medicine should be used with extreme caution in patients with a known history of hepatitis B due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient. Screening for hepatitis B prior to beginning treatment with this medicine is advised.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Amlodipine

Digoxin

Citalopram

Amiodarone

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by stopping the hepatitis C virus from multiplying in the body. This helps in inhibiting the spread of the infection.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous antivirals

Schedule

Schedule H

Ledipasvir - DrugBank [Internet]. Drugbank.ca. 2018 [cited 9 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB09027

Ledipasvir [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 9 April 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Ledipasvir#section=Pharmacological-Classes

[Internet]. Accessdata.fda.gov. 2018 [cited 9 April 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205834s001lbl.pdf

[Internet]. Medicines.org.uk. 2018 [cited 9 April 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.3461.pdf

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Information on this page was last updated on 11 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.