Home >
Medicine Info >
Ledifos Tablet
Loading interface...

Ledifos Tablet

Manufactured byHETERO HEALTHCARE LTD
ContainsLedipasvir (90 mg) + Sofosbuvir (400 mg)
Description
Ledifos Tablet is a combination medicine composed of Sofosbuvir and Ledipasvir. It is used in the treatment of chronic hepatitis C infection. It is an infection caused by a virus that attacks your liver and leads to pain and swelling. Ledifos Tablet works by stopping the growth of viruses in your body, thus reducing the infection. This medicine is not recommended for use if you have a known history of hepatitis B infection (serious liver infection caused by the hepatitis B virus). Ledifos Tablet may cause side effects like chills, headache, irritability, diarrhoea, etc. Most of them are temporary and resolved on their own. Consult your doctor if these side effects are persistent or bothering you. Do not take this medicine if you are allergic to it. Ledifos Tablet can be taken with or without food, as prescribed by your doctor. Your dose will be dependent on the severity of your condition. Try to take this medicine same time every day to maintain a constant level of medicine in your body. Do not stop taking this medicine without consulting with your doctor as your symptoms could come back. Ledifos Tablet is not recommended to be used in children below 3 years of age. Inform your doctor about all your current medications and medical conditions. This can help your doctor to adjust your dose to avoid any side effects. If you are pregnant or breastfeeding, consult your doctor before taking this medicine.
QUICK LINKS:
Side effectsConcernsUsage

Side effects

Major & minor side effects for Ledifos Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Difficulty in falling asleep
  • Irritability
  • Chest pain
  • Decreased appetite
  • Muscle pain and cramps

Uses of Ledifos Tablet

What is it prescribed for?

  • Chronic Hepatitis C
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Ledifos Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Ledifos Tablet remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Ledifos Tablet.
  • Can this medicine be taken during pregnancy?
    There is no clinically established data available on the use of Ledifos Tablet in pregnant women. Therefore, consult your doctor to discuss all risks and benefits before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Ledifos Tablet has not been studied in breastfeeding mothers being treated for Hepatitis C infection. Therefore, consult your doctor before taking this medicine to understand the risks and benefits associated with this medicine.

Allergy

Ledifos Tablet is not recommended if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Ribavirin and peginterferon alfa

When Ledifos Tablet is used in combination with ribavirin and/or peginterferon alfa, the contraindications applicable to those medicines are also applicable to combination therapies. This can complicate your treatment. Hence, combining these medicines with Ledifos Tablet is not recommended.
Warnings for special population

Pregnancy

There is no clinically established data available on the use of Ledifos Tablet in pregnant women. Therefore, consult your doctor to discuss all risks and benefits before taking this medicine.

Breast-feeding

Ledifos Tablet has not been studied in breastfeeding mothers being treated for Hepatitis C infection. Therefore, consult your doctor before taking this medicine to understand the risks and benefits associated with this medicine.
General warnings

Hepatitis B

Ledifos Tablet should be used with caution if you have a known history of hepatitis B due to the increased risk of worsening your condition. Your doctor may replace this medicine with another suitable alternative in such cases. Your doctor may also prescribe tests for Hepatitis B infection before starting the treatment,

Kidney failure

Ledifos Tablet should be used with caution if you have kidney problems as a diseased kidney will not be able to filter the medicine properly. This can increase the risk of toxicity. Your doctor will monitor your kidney functions closely and/or adjust your dose if required.

Use in children

Ledifos Tablet is not recommended for use in children below 3 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose of Ledifos Tablet as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment in case of an overdose of Ledifos Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Rifampicin

Fosphenytoin

Digoxin

Amiodarone

Linagliptin

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Ledifos Tablet as prescribed by your doctor. Drink plenty of water with it to avoid stomach irritation. Do not break, crush or chew the tablet. Do not take this medication for a longer duration than suggested by your doctor. Consult your doctor before you stop taking this medication. Keep Ledifos Tablet away from children and pets. Do not use this medicine after the expiry date. Throw away the unused medicine safely after the expiry date. Your doctor may closely monitor your liver functions while you are on this therapy. If you develop any undesired effects, or if your condition is worsening, inform your doctor immediately.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Ledifos Tablet is an antiviral medication. It works by lowering the load of the hepatitis C virus in the body and removing the virus from the blood over a period of time. This helps in stopping the spread of the infection.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiviral combinations

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2022. DailyMed - HARVONI ACCESS- ledipasvir and sofosbuvir tablet, film coated. [online] Available at: < [Accessed 22 March 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a1c555d-2fdf-4150-8ace-dbc770c226bf>

Medicines.org.uk. 2022. Harvoni 90 mg/400 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 22 March 2022].

https://www.medicines.org.uk/emc/product/3461#PHARMACEUTICAL_PARTS>

Ebs.tga.gov.au. 2022. TGA eBS - Product and Consumer Medicine Information Licence. [online] Available at: < [Accessed 22 March 2022].

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2015-PI-01772-1&d=201809041016933&d=20220322172310101>

Accessdata.fda.gov. 2022. [online] Available at: < [Accessed 22 March 2022].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205834s000lbl.pdf>
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 9 Jan 2023

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.