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Largesic (50/500 mg) Tablet

Manufactured byLark Laboratories Ltd.
ContainsDiclofenac (50 mg) + Paracetamol (500 mg)
Description
Largesic (50/500 mg) Tablet is a combination of Diclofenac and Paracetamol. It is used to reduce pain due to various conditions such as headache, toothache, backache, menstrual pain, sprains, and strains. It also provides effective relief from pain, stiffness, and swelling due to ankylosing spondylitis (pain due to fusing of bones in the spine), osteoarthritis (pain on movement due to wearing of the protective covering at the ends of the bones) and rheumatoid arthritis (a type of arthritis affecting the small joints). This medicine blocks the release of a chemical that causes pain and swelling, thus providing pain relief. Largesic (50/500 mg) Tablet shows common side effects like nausea, vomiting, heartburn, stomach pain, loss of appetite, and diarrhoea. Do not use this medicine if you are allergic to it. In some patients, this medicine may cause dizziness and drowsiness. Do not drive or operate machines if you feel drowsy or dizzy after taking this medicine. Largesic (50/500 mg) Tablet can be taken with food, milk, or an antacid to avoid stomach irritation. Largesic (50/500 mg) Tablet relieves pain and swelling due to arthritic conditions but does not cure it. Do not self-medicate or use it beyond the prescribed duration. Largesic (50/500 mg) Tablet should be used with caution in people having a history of stomach or intestinal bleeding, heart troubles, asthma and severe liver and kidney troubles. Inform your doctor if you have a history of any medical condition or if you are taking any medication. Also, inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding.

Side effects

Major & minor side effects for Largesic (50/500 mg) Tablet

  • Stomach pain
  • Constipation
  • Diarrhoea
  • Nausea and Vomiting
  • Skin rash
  • Fatigue
  • Sore mouth and tongue
  • Bloody or cloudy urine
  • Loss of appetite
  • Dizziness
  • Heartburn

Uses of Largesic (50/500 mg) Tablet

What is it prescribed for?

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Dysmenorrhea
  • Ankylosing Spondylitis
  • Mild to moderate pain
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Largesic (50/500 mg) Tablet provides relief from your aches or cramps and makes you feel better in 15-30 minutes.
  • How long do the effects of this medicine last?
    The effect of Largesic (50/500 mg) Tablet lasts for an average duration of 10-12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while taking Largesic (50/500 mg) Tablet as it may increase the risk of side effects like confusion, dizziness, and impaired judgment, and stomach bleeding.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported for Largesic (50/500 mg) Tablet.
  • Can this medicine be taken during pregnancy?
    Largesic (50/500 mg) Tablet is not recommended for use during pregnancy due to the risk of harmful effects to your foetus. Inform your doctor about your pregnancy before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Largesic (50/500 mg) Tablet is not recommended for use in breastfeeding women. If required, it should only be used upon your doctor's recommendation.

Allergy

Avoid taking Largesic (50/500 mg) Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Kidney failure

Largesic (50/500 mg) Tablet is not recommended for use in people having severe kidney problems that are associated with the excessive use of painkillers. If you have pre-existing kidney problems, consult your doctor before taking this medicine.

Coronary Artery Bypass Surgery (CABG)

Coronary Artery Bypass Surgery (CABG) is a surgical procedure to restore normal blood flow to the heart muscle. Do not use Largesic (50/500 mg) Tablet to relieve pain after heart surgery as it may cause serious side effects.

Stomach and intestinal bleeding

Largesic (50/500 mg) Tablet is not recommended for use in conditions such as active ulcers, stomach and intestinal bleeding as it may worsen your condition.

Severe liver impairment

Largesic (50/500 mg) Tablet is absorbed and broken down in your liver. This medicine is not recommended if you already have severe liver problems as it may cause further damage to your liver.
Warnings for special population

Pregnancy

Largesic (50/500 mg) Tablet is not recommended for use during pregnancy due to the risk of harmful effects to your foetus. Inform your doctor about your pregnancy before taking this medicine.

Breast-feeding

Largesic (50/500 mg) Tablet is not recommended for use in breastfeeding women. If required, it should only be used upon your doctor's recommendation.
General warnings

Liver diseases

Largesic (50/500 mg) Tablet is absorbed and broken down in your liver. This medicine is not recommended if you already have liver problems as it may cause further damage to your liver.

Driving or operating machines

Largesic (50/500 mg) Tablet causes sleepiness, blurred vision or dizziness in some people. If you experience such side effects, do not drive vehicles and operate machines after taking this medicine.

Skin rash

Largesic (50/500 mg) Tablet may cause serious skin allergies. If you develop signs and symptoms like rashes, hives (painful eruptions that itch and sting), or other allergic symptoms, stop taking this medicine and inform your doctor immediately.

Water retention and oedema

Largesic (50/500 mg) Tablet may cause water retention and oedema (swelling of the skin due to trapped water beneath the skin) in some people. This medicine has to be taken with caution if you have any medical condition related to your heart and kidney, high blood pressure or if you are taking any other medicines that may affect your kidney.

Kidney disease

Largesic (50/500 mg) Tablet should be used with caution in people having kidney troubles as it may lead to progressive kidney damage over time.

Missed Dose

If you have forgotten to take Largesic (50/500 mg) Tablet at a scheduled time, take it as soon as you remember. However, if it is time for your next dose, skip the dose. Do not take two doses at once to make up for the missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment in case you suspect an overdose of Largesic (50/500 mg) Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while taking Largesic (50/500 mg) Tablet as it may increase the risk of side effects like confusion, dizziness, and impaired judgment, and stomach bleeding.
Interaction with Medicine

Carbamazepine

Methotrexate

Phenytoin

Ramipril

Sodium Nitrite

Aspirin

Warfarin

Disease interactions

Asthma

Asthma is an allergic reaction causing narrowing and excess mucous secretion in the air pathway of your lungs leading to breathing difficulty. People with asthma may experience allergic reactions while taking Largesic (50/500 mg) Tablet. Hence, it is not recommended for use in people with asthma, especially those who had experienced allergic reactions with the use of other non-steroidal anti-inflammatory medicines.

Gastro-Intestinal toxicity

Long term use of Largesic (50/500 mg) Tablet can cause damage to the stomach and intestine. Serious conditions like bleeding or the development of ulcers in the linings of the stomach or intestinal wall can occur. Any symptom indicating ulceration and bleeding like indigestion, the appearance of coffee coloured dry blood in stools or vomiting of blood should be reported to your doctor immediately.

Heart disease

Long-term use of Largesic (50/500 mg) Tablet may increase the risk of a heart attack in people with pre-existing heart conditions. It is not recommended for use in such people. It is also not suitable for treating pain after heart surgery.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

Largesic (50/500 mg) Tablet can interfere with a urine test and may give a false-positive result. It is advised to inform your doctor and lab technician about all your current medicines before undergoing any lab test.
Take Largesic (50/500 mg) Tablet with or after food to avoid stomach upset. Do not crush, break or chew the tablet. Take the medicine at around the same time daily. Avoid self-medication and take this medicine only for the prescribed duration. Avoid alcohol consumption while taking this medicine as it may elevate dizziness or drowsiness and stomach bleeding. Do not drive or operate machines if you feel dizzy or drowsy.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Largesic (50/500 mg) Tablet contains Diclofenac and Paracetamol that stops the release of a chemical called prostaglandins, that increases pain and swelling. Thus, this medicine provides relief from your aches and makes you feel better.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Non-steroidal anti-inflammatory agents, Analgesics

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Acetaminophen. [online] Available at: < [Accessed 22 April 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/1983>

Pubchem.ncbi.nlm.nih.gov. 2021. Diclofenac. [online] Available at: < [Accessed 17 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac>

Medicines.org.uk. 2021. Paracetamol 500mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 28 July 2021].

https://www.medicines.org.uk/emc/product/10817/smpc>

Medicines.org.uk. 2021. Diclofenac Sodium 50mg Gastro-Resistant Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 27 July 2021].

https://www.medicines.org.uk/emc/product/2660>

Fdaghana.gov.gh. 2021. [online] Available at: < [Accessed 28 July 2021].

https://fdaghana.gov.gh/img/pils/Pedol%20Tablets%20(Paracetamol%20and%20Diclofenac%20Sodium).pdf>
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Information on this page was last updated on 3 Sep 2021

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