Lapatinib

Description

Lapatinib is an anticancer agent which is used in the treatment of breast cancer. It should be used under the supervision of a qualified physician. It is used in a combination with other anti-cancer medications.

Side effects

Major & minor side effects for Lapatinib

  • Decreased appetite or loss of appetite
  • Difficulty in breathing
  • Stomach pain
  • Back pain or Joint pain
  • Clay colored stools
  • Fast or irregular heartbeat
  • Yellow eyes or skin
  • Dark urine
  • Headache
  • Severe diarrhea
  • Fatigue
  • Skin rash
  • Nausea or vomiting

Uses of Lapatinib

What is it prescribed for?

  • HER2- overexpressing advanced or metastatic breast cancer
  • Hormone-positive and HER2-positive metastatic breast cancer
  • Hormone receptor-negative metastatic breast cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use if you have a known allergy to lapatinib or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Cardiac disorders

This medicine should be used with caution in patients suffering from any cardiac disorders due to the increased risk of severe adverse effects. Close monitoring of cardiac function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Thrombocytopenia

This medicine should be used with caution in patients with decreased platelet counts due to the increased risk of worsening of the patient’s condition. Regular monitoring of platelet count is necessary prior to each dose of this medicine. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

QT interval prolongation

This medicine should be used with extreme caution in patients who have or may develop prolongation of QT interval due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Severe cutaneous adverse reactions

This medicine may cause severe cutaneous adverse reactions or life-threatening reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, etc. in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Severe diarrhea

This medicine may cause severe diarrhea in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clonazepam

Omeprazole

Teriflunomide

Digoxin

Cisapride

Disease interactions

Cardiac Dysfunction

This medicine should be used with extreme caution in patients with cardiac dysfunction due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Lung impairment

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine one hour before or after food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Antineoplastics, HER2 inhibitors, EGFR inhibitors

Schedule

Schedule H

[Internet]. India-pharma.gsk.com. 2019 [cited 26 February 2019]. Available from:

https://india-pharma.gsk.com/media/701378/tykerb-tablets.pdf

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 13 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Lapatinib

[Internet]. Medicines.org.uk. 2018 [cited 13 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6292.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 13 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022059s007lbl.pdf

[Internet]. Drugbank.ca. 2018 [cited 13 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB01259

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Information on this page was last updated on 26 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.