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Lami Plus Tablet
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Lami Plus Tablet

Manufactured byMCNEIL & ARGUS PHARMACEUTICALS LTD
ContainsLamivudine (150 mg) + Zidovudine (300 mg) + Nevirapine (200 mg)
Description
Lami Plus Tablet is a combination medicine which is used to treat human immunodeficiency virus (HIV) infections in patients weighing at least 35 kg. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition of the patient.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Lami Plus Tablet

  • Chills and fever
  • Headache
  • Tiredness
  • Loss of appetite
  • Depression
  • Stuffy nose
  • Indigestion
  • Sore throat
  • Pale skin
  • Diarrhea
  • Nausea and Vomiting
  • Difficulty with bowel movements
  • Weight loss
  • Heartburn
  • Abdominal and stomach cramps
  • Dark colored urine
  • Skin Rash
  • Muscle pain and cramps

Uses of Lami Plus Tablet

What is it prescribed for?

  • HIV infection
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to lamivudine, zidovudine, nevirapine or any other inactive ingredients present along with the formulation.

Moderate to severe liver impairment

This medicine is not recommended for use in patients with a moderate to severe liver impairment due to the increased risk of worsening of the patient's condition.

Post-exposure prophylaxis

This medicine is not recommended for use in post-exposure prophylaxis treatment for HIV infection.

Kidney impairment

This medicine is not recommended for use in patients with creatinine clearance less than 50 ml/min due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Immune reconstitution syndrome

This medicine should be used with caution due to the increased risk of Immune reconstitution syndrome. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver diseases

This medicine should be used with extreme caution in patients with mild liver impairment due to the increased risk of worsening of the patient's condition. Liver function should be assessed before initiating the treatment. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition. This medicine is not recommended for use in patients with a moderate to severe liver impairment.

Pancreatitis

This medicine may rarely cause pancreatitis in some patients. Report any unusual symptoms to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis.

Lactic acidosis

This medicine should be used with caution due to the increased risk of Lactic acidosis. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Fat redistribution

This medicine may cause fat gain or fat loss from the body. This may result in peripheral wasting, facial wasting, breast enlargement, and Cushingoid appearance. Close monitoring of body weight and body fat distribution is necessary while receiving this medicine. Any changes in the body should be informed to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Skin rash

This medicine should be used with caution due to the increased risk of serious and life-threatening skin reactions. Seek emergency medical treatment in case of any unusual reactions such as rashes or blisters. Therapy with this medicine may need to be discontinued based on the clinical condition of the patient.

Driving or operating machinery

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clarithromycin

Clozapine

Methotrexate

Atazanavir

Atorvastatin

Etodolac

Ganciclovir

Fenofibrate

Efavirenz

Disease interactions

Bone marrow suppression

This medicine should be used with caution in patients with a known history of bone marrow suppression due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Myopathy

This medicine should be used with caution in patients with a known history of myopathy due to the increased risk of worsening of the patient's condition. Report any symptoms such as dark-colored urine, muscle pain, weakness, etc. to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients with mild liver impairment due to the increased risk of worsening of the patient's condition. Liver function should be assessed before initiating the treatment. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition. This medicine is not recommended for use in patients with a moderate to severe liver impairment.

Pancreatitis

This medicine may cause pancreatitis in some patients. Report any unusual symptoms to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis.

Skin Rash

This medicine should be used with extreme caution due to the increased risk of serious and life-threatening skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions characterized by a rash. Seek emergency medical treatment in case of any unusual reactions such as a rash or blisters. Replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Complete the course of treatment to prevent the spread of the infection. Close monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antiviral combinations

Schedule

Schedule H

[Internet]. Hivdb.stanford.edu. 2019 [cited 1 April 2019]. Available from:

https://hivdb.stanford.edu/pages/linksPages/NVP_3TC_AZT_GenericCombination.pdf

[Internet]. Extranet.who.int. 2019 [cited 1 April 2019]. Available from:

https://extranet.who.int/prequal/sites/default/files/HA524part3v1.pdf

Duovir-N Tablets [Internet]. CiplaMed. 2019 [cited 1 April 2019]. Available from:

https://ciplamed.com/content/duovir-n-tablets

Lamivudine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 29 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00709
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Information on this page was last updated on 10 Jul 2019

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