L-Methylfolate is a naturally occurring form of vitamin B that is necessary for maintaining important functions in the body. It is a vitamin supplement used to treat nutritional deficiency and anaemia (low number of red blood cells). The higher dose of this medicine (7.5mg to 15mg) is also used as an adjunctive in treating decreased folate levels or hyperhomocysteinemia (high levels of amino acid in the blood) in Schizophrenia (a mental disorder that affects a person's ability to think, feel, and perceive reality) or Depression (a mood disorder with a persistent feeling of sadness and loss of interest). L-Methylfolate may cause common side effects such as diarrhoea, headache, nausea, and vomiting. Consult your doctor if these symptoms persist or worsen. L-Methylfolate may be taken with or without food. Take it in the dose and duration advised by your doctor. Avoid taking more or less than the recommended dose. Take it at the same time every day to maintain a constant level of this medicine in your body and for ease of remembering. L-Methylfolate is not recommended for use if you are allergic to it. Inform your doctor about your pre-existing medical conditions and current medications to avoid any undesired effects. This medicine may be used during pregnancy and while breastfeeding upon your doctor's recommendation.

Side effects

Major & minor side effects for L-Methylfolate

  • Confusion
  • Nausea
  • Sleep disturbances
  • Diarrhoea
  • Upset stomach

Uses of L-Methylfolate

What is it prescribed for?

  • Folic acid deficiency
  • Schizophrenia
  • Major depressive disorder
  • Megaloblastic Anemia
Read More

Commonly asked questions

  • Onset of action
    The amount of time required for L-Methylfolate to show its action is not clinically established.
  • Duration of effect
    The amount of time for which L-Methylfolate remains effective in the body is clinically not established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies have been reported with L-Methylfolate.
  • Usage in pregnancy?
    L-Methylfolate may be used during pregnancy upon your doctor's recommendation.
  • Usage while breast-feeding?
    L-Methylfolate may be used while breastfeeding upon your doctor's recommendation.


Avoid taking L-Methylfolate if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population


L-Methylfolate may be used during pregnancy upon your doctor's recommendation.


L-Methylfolate may be used while breastfeeding upon your doctor's recommendation.
General warnings

Vitamin B12 deficiency anaemia

L-Methylfolate should not be used alone to treat anaemia due to vitamin B12 deficiency as it may increase the risk of worsening your health condition.

Other medicines

L-Methylfolate may interact with other medicines, causing altered effects of either medicine or increased risk of side effects. Hence inform your doctor about all your current medications, including herbs and supplements, before starting the treatment with this medicine.

Missed Dose

Avoid missing a scheduled dose of L-Methylfolate. Take the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.


Do not take more than the prescribed dose of L-Methylfolate. Consult your doctor if you suspect an overdose of this medicine for further guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol


Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.


Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine



Disease interactions


L-Methylfolate should be used with caution if you have a history of bipolar disorder (extreme mood swings with emotional highs and lows). This medicine may cause mood elevation and further worsen your condition. Consult your doctor before taking this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
Take L-Methylfolate as instructed by your doctor. It can be taken with or without food. Do not chew or crush the tablet/capsule in the mouth. Do not take more or less than the prescribed dose. Do not stop the use of L-Methylfolate without consulting your doctor.

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
L-Methylfolate is essential for the production of certain vital components that are necessary for the maintenance of normal body functions.
Legal Status









Schedule H

Dailymed.nlm.nih.gov. 2022. L-METHYLFOLATE CALCIUM 7.5mg Tablets L-METHYLFOLATE CALCIUM 15mg Tablets. [online] Available at: [Accessed 27 July 2022].


Intetlab.com. 2022. [online] Available at: [Accessed 27 July 2022].


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Information on this page was last updated on 3 Aug 2022


We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.