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Kryxana 200 mg Tablet

Manufactured byNOVARTIS INDIA LTD
ContainsRibociclib
Description

Kryxana 200 mg Tablet is an anticancer medicine used in combination with other medicines to treat certain types of breast cancer. Close monitoring of blood cell count is recommended during treatment with this medicine. This medicine is not recommended for use in patients below 18 years of age.

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Side effects

Major & minor side effects for Kryxana 200 mg Tablet

  • Bloating
  • Black or Tarry stools
  • Frequent urge to urinate
  • Chest tightness
  • Lower back or side pain
  • Unusual tiredness
  • Irregular heartbeat
  • Fainting
  • Rapid weight gain/loss
  • Tingling of hands and feet
  • Hairloss
  • Nausea
  • Decreased appetite
  • Sleep disturbances
  • Stomach pain

Uses of Kryxana 200 mg Tablet

What is it prescribed for?

  • Breast cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to Ribociclib or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Neutropenia

This medicine may cause neutropenia (a decrease in white blood cells) in some patients. A decrease in white blood cell count may render the patient prone to serious and opportunistic infections. Report any unusual symptoms such as a fever, chills, sore throat, etc. to the doctor immediately. Close monitoring of blood cell counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Infections

Since this medicine can cause bone marrow suppression, the patients are susceptible to serious and opportunistic infections. Report any symptoms such as a fever, chills, shortness of breath, sore throat, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Contraception

Use of this medicine may increase the risk of harm to the unborn baby in pregnant women. Effective contraception is advised for women with the childbearing potential to avoid such risks.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause dizziness, tiredness, blurred vision, etc. in some patients. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.

QT interval prolongation

This medicine should be used with extreme caution in patients who have or may develop prolongation of QT interval due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not double your dose to make up for the missed dose. Contact your doctor for further instructions if you miss more than one scheduled dose of this medicine.

Overdose

Seek emergency medical treatment or contact the doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Oxycodone

Live attenuated vaccines and related products

Adalimumab

Carbamazepine

Clarithromycin

Phenobarbital

Disease interactions

Lung impairment

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Pomegranate, grapefruit or its juice may significantly increase the blood levels of this medicine. This may cause severe side effects such as nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, etc. Hence, the consumption of pomegranate, grapefruit or its juice is not recommended during treatment with this medicine.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger or smaller amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Kryxana 200 mg Tablet blocks the action of certain proteins to slow down the growth and spread of cancer cells. This delays the progression of the disease.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

CDK 4/6 inhibitors, Antineoplastics

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2019 [cited 26 March 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209092s000lbl.pdf

Ribociclib - DrugBank [Internet]. Drugbank.ca. 2019 [cited 26 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB11730

DailyMed - Kisqali - ribociclib tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 26 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aaeaef94-f3f5-4367-8ea2-b181d7be2da8

Ribociclib: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 30 May 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a617008.html
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Information on this page was last updated on 30 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.