Karplat 450 MG Infusion

Manufactured byCadila Pharmaceuticals Ltd.
ContainsCarboplatin
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Description

Karplat 450 MG Infusion is an anticancer agent which is used in the treatment of cancer of the female reproductive system. It should be used under the supervision of a qualified physician. Close monitoring of kidney function and blood cell count are necessary while receiving this medication.

Substitutes

List of substitutes for Karplat 450 MG Infusion

Side effects

Major & minor side effects for Karplat 450 MG Infusion

  • Pain at the injection site
  • Low WBC and Platelet count
  • Fever and chills
  • Difficult or painful urination
  • Skin rash
  • Unusual bleeding
  • Tingling or numbness of the hands and feet
  • Blurred vision
  • Ringing or buzzing in the ears
  • Nausea and Vomiting
  • Diarrhea
  • Loss of appetite

Uses of Karplat 450 MG Infusion

What is it prescribed for?

  • Ovarian Cancer
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 2 to 4 hours after intravenous injection.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in patients with known allergy to Karplat 450 MG Infusion or other platinum-containing compounds.

Significant bleeding

Not recommended in patients with the bleeding disorder.

Severe myelosuppression

Not recommended in patients with low white blood cell and platelet count.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is not recommended in breastfeeding women.
General warnings

Impaired kidney function

This medicine may cause severe kidney injury. The risk may increase if taken with aminoglycoside antibiotics. Close monitoring of serum creatinine, urea, and sodium levels is necessary. Do not administer this medicine more than once every 3 to 4 weeks.

Hearing impairment

This medicine may cause the hearing problem which is more common in children. Audiometric testing should be performed before initiating the treatment and also before every dose. Any symptoms of the hearing problem should be reported to the doctor.

Allergy

This medicine may cause serious skin reactions. Discontinue the treatment if any symptoms of allergy appear and do not restart.

Blood cell count

This medicine may lower the white blood cells and platelets. Close monitoring of blood cell count is necessary. Do not start the treatment if the cell count is low.

Infections

The chances of occurring infections are more in patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Missed Dose

It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Vancomycin

Atorvastatin

Live vaccines

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is given in multiple cycles. It is important to receive the every scheduled dose and make a note of next scheduled dose. Close monitoring of blood cells counts and kidney function.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by stopping the growth of cancer cells by inhibiting the DNA synthesis.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Alkylating agents

Schedule

Schedule H

DailyMed - Carboplatin injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 25 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=91bc1221-4191-4970-88e3-a1659bc75392

Carboplatin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 25 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a695017.html

[Internet]. 2017 [cited 25 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/24674

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 25 April 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 25 April 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~ZVEhIb:1
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