Ixabepilone

Description

Ixabepilone is used to treat advanced or metastatic breast cancer in patients who have not adequately responded to other cancer medicines. It is either used alone or in a combination with capecitabine.

Side effects

Major & minor side effects for Ixabepilone

  • Unusual tiredness or weakness
  • Black or tarry stools
  • Hair loss
  • Muscle pain
  • Chest pain
  • Diarrhea
  • Headache and dizziness
  • Cough
  • Pale skin
  • Weight gain
  • Dry mouth
  • Bleeding gums

Uses of Ixabepilone

What is it prescribed for?

  • Breast cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to Ixabepilone or any other inactive ingredients present along with it.

Low platelet count and Low white blood cell count

This medicine is not recommended for use in patients who have a low platelet count (<100,000 cells/mm3) or a low white blood cell (neutrophil) count (<1500 cells/mm3) due to increased risk of serious side effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Severe allergic reactions

Use of this medicine may cause severe allergic reactions and injection site reactions in some patients. In case of any such reactions, treatment should be discontinued and appropriate medical therapy should be instituted immediately.

Liver impairment

This medicine should be used with caution in patients with mild to moderate liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular disorders

Usage of this medicine may increase the risk of heart-related complications. Caution is advised while initiating the therapy in patients with any active heart condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Bonemarrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Peripheral neuropathy

This medicine may cause symptoms of peripheral neuropathy such as numbness, tingling, or burning in the hands or feet. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live attenuated vaccines and related products

Isoniazid

Etanercept

Infliximab

Chloramphenicol

Amiodarone

Disease interactions

Liver impairment

This medicine should be used with caution in patients with liver function impairment due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Grapefruit may significantly increase the undesired effects of Ixabepilone. Hence, the consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stopping the growth of cancer cells in the body.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Antineoplastics, Mitotic inhibitors

Schedule

Schedule H

[Internet]. Drugbank.ca. 2019 [cited 3 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB04845

[Internet]. Ixempra.com. 2019 [cited 3 January 2019]. Available from:

http://ixempra.com/

[Internet]. Ixempra.com. 2019 [cited 3 January 2019]. Available from:

http://ixempra.com/downloads/full_pi.pdf

[Internet]. Accessdata.fda.gov. 2019 [cited 3 January 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022065s002lbl.pdf

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Information on this page was last updated on 2 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.