Itolizumab

Description

Itolizumab is a new medicine developed and approved in India for the treatment of psoriasis. It may also be used for the treatment of certain other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, etc.

Side effects

Major & minor side effects for Itolizumab

  • Injection site reactions
  • Upper respiratory tract infection
  • Fever
  • Itching
  • Diarrhea
  • Dizziness

Uses of Itolizumab

What is it prescribed for?

  • Psoriasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to itolizumab or any other inactive ingredients present along with it.

Active infections

This medicine is not recommended for use in patients who are suffering from active severe infections due to the increased risk of worsening of the patient's condition.

Severe immunocompromise

This medicine is not recommended for use in patients with severe immunocompromise or patients receiving immunosuppressant therapy since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.
General warnings

Infusion related reactions

Usage of this medicine may cause symptoms like fever, chills, nausea, vomiting, dizziness, dyspnea, fall in blood pressure, etc. in some patients. Appropriate symptomatic treatment, dose adjustments, or discontinuation of therapy may be necessary in these cases based on the clinical condition.

Infections

This medicine should be used with extreme caution in patients with a history of infections; it is not recommended for use in case of active infections due to the increased risk of worsening of the patient’s condition. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Administration

This medicine should be infused over a duration of at least 2 hours.

TB testing

Prior to the initiation of therapy with this medicine, the patient should be evaluated for any latent TB infections by TB skin test or chest x-ray to avoid any possible adverse effects or complications. It is advised to withhold the therapy with this medicine if these tests are positive.

Driving or Operating machinery

Use of this medicine may cause dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience dizziness during treatment with this medicine.

Missed Dose

This medicine is usually given in multiple cycles. If you miss a scheduled appointment for receiving a dose of this medicine, call your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live attenuated vaccines and related products

Disease interactions

Bone marrow suppression

This medicine should be used with extreme caution in patients with a known history of bone marrow suppression since it may worsen the patient's condition. Close monitoring of complete blood cell counts is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Renal impairment

This medicine should be used with caution in patients with renal diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered by a qualified healthcare professional in the hospital or clinical setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines including any herbs and supplements as well as your medical conditions before receiving this medicine. Report any unusual and significant side effects to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by blocking the action of certain specific substances in the body that cause inflammation and other associated complications.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

CD6 monoclonal antibodies

Schedule

Schedule H

[Internet]. Biocon.com. 2018 [cited 11 September 2018]. Available from:

https://www.biocon.com/biocon_products_bio_BF_alzb.asp

Itolizumab in Psoriasis- NCBI [Internet]. Ncbi.nlm.nih.gov. 2018 [cited 11 September 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527725/

[Internet]. 2018 [cited 11 September 2018]. Available from:

https://www.sciencedirect.com/science/article/pii/S2211283912000263

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Information on this page was last updated on 27 Dec 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.