Istamet (1000/50 mg) Tablet

Manufactured bySun Pharma Laboratories Ltd.
ContainsMetformin (1000 mg) + Sitagliptin (50 mg)
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Description

Istamet (1000/50 mg) Tablet is a combination medicine used for the treatment of type 2 diabetes mellitus. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients below 18 years of age.

Substitutes

List of substitutes for Istamet (1000/50 mg) Tablet

Side effects

Major & minor side effects for Istamet (1000/50 mg) Tablet

  • Anxiety
  • Chills
  • Blurred vision
  • Confusion
  • Cough
  • Fever
  • Sore throat
  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Hypoglycemia
  • Lactic Acidosis
  • Weakness
  • Chest discomfort
  • Headache
  • Running nose
  • Belching and Heartburn
  • Swollen joints

Uses of Istamet (1000/50 mg) Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-3 hours of administration.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit-forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to sitagliptin, any other dipeptidyl peptidase 4 inhibitors, metformin, or any other biguanides.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Use in children

This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.

Bullous pemphigoid

This medicine should be used with caution due to the increased risk of bullous pemphigoid, a hypersensitivity reaction of the skin. Any unusual symptoms such as skin blisters or skin rashes should be reported to the doctor on priority. Therapy with the medicine may be discontinued based on the clinical condition of the patient.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with a known history of diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Type 1 diabetes mellitus

This medicine is not recommended for use in patients with type 1 diabetes mellitus.

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients with a known history of kidney disease due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Alcohol use

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Clozapine

Estradiol

Gatifloxacin

Iodinated Contrast Media

Aloe Vera

Acetazolamide

Benazepril

Bexarotene

Bumetanide

Disease interactions

Pancreatitis

This medicine should be used with extreme caution in patients with a known history of pancreatitis due to the increased risk of recurrent pancreatitis. Report any symptoms such as abdominal pain, nausea, vomiting, etc. to the doctor immediately. Therapy with the medicine may be discontinued based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with extreme caution in patients with a history of kidney diseases due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition.

Lactic Acidosis

This medicine may cause lactic acidosis in some patients. This risk is especially higher in patients with kidney diseases, heart diseases, or septicemia. Close monitoring of blood glucose levels, kidney function, heart function, and liver function may be required for such patients based on the clinical condition. Report any symptoms such as fatigue, breathing difficulty, increased sleep, nausea, vomiting, diarrhea, irregular heartbeat, etc. to the doctor immediately. Appropriate corrective measures and discontinuation of therapy may be required in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as prescribed by the doctor. It is advised to take this medicine just before meals or with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. Do not change the dose or duration of use without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Sitagliptin increases insulin and lowers glucagon production. The combination is thus better effective than monotherapy in lowering the blood glucose levels.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

[Internet]. 2017 [cited 25 September 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.23112.latest.pdf

[Internet]. 2017 [cited 25 September 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541863/

DailyMed - Januvia- sitagliptin tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f85a48d0-0407-4c50-b0fa-7673a160bf01

DailyMed - Janumet- sitagliptin and metformin hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 29 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d19c7ed0-ad5c-426e-b2df-722508f97d67
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