IncobotulinumtoxinA
Description
IncobotulinumtoxinA is a chemical substance produced from a bacteria called Clostridium botulinum which is used for the treatment of spasticity of the upper limb, cervical dystonia (severe spasms in the neck muscles), certain eye muscle conditions that occur due to nerve disorders, and chronic drooling caused by neurological disorders in adult patients. It is also used for the improvement in the appearance of moderate to severe glabellar lines (wrinkles between the eyebrows) in adults.
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Side effects
Major & minor side effects for IncobotulinumtoxinA
- Difficulty with swallowing
- Dry eyes
- Muscle pain
- Blurred vision
- Headache
- Chest tightness
- Dizziness and Drowsiness
- Skin rash
- Pain at the injection site
- Dry mouth
- Swelling of the eyelids
Uses of IncobotulinumtoxinA
What is it prescribed for?
- Upper limb spasticity
- Cervical Dystonia
- Blepharospasm
- Sialorrhea
- Glabellar Lines
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Concerns
Commonly asked questions
- Onset of actionThe amount of time taken by this medicine to show its effect is subject to vary based on the individuals and intended use.
- Duration of effectThe amount of time for which this medicine remains effective is subject to vary based on the individuals and intended use.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to IncobotulinumtoxinA or any other inactive ingredients present along with the formulation.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Severe allergic reactions
Severe allergic reactions or hypersensitivity reactions, including anaphylactic shock, low blood pressure, breathing difficulties, urticaria (skin rash), etc. may occur with this medicine. If symptoms of allergic reactions occur, discontinue immediately and initiate appropriate treatment.
Driving or operating machinery
Use of this medicine may cause loss of strength, drowsiness, dizziness, drooping eyelids, or visual disturbances in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery immediately after treatment with this medicine.
Infections
This medicine should not be used in patients with an infection at the proposed therapy site since it may worsen the patient's existing condition.
Use in children
This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.
Missed Dose
Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.
Overdose
Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Nortriptyline
Streptomycin
Atracurium
Amoxapine
Gentamicin
Imipramine
Disease interactions
Respiratory Diseases
This medicine should be used with extreme caution in patients with respiratory diseases due to the increased risk of breathing difficulties. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Dysphagia
This medicine should be used with extreme caution in patients with pre-existing swallowing disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Narrow angle glaucoma
This medicine should be used with extreme caution to treat blepharospasm in patients with narrow-angle glaucoma due to the increased risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Close monitoring of the patient for the development of any excessive muscle weakness, severe dysphagia, and respiratory compromise is recommended. The botulinum toxin should only be used if the benefit of treatment is considered to outweigh the risk.
Miscelleneous
How it works
This medicine works by inhibiting the release of a chemical called acetylcholine that causes muscle contraction.
Legal Status
Classification
Category
Skeletal muscle relaxants, Neuromuscular blocking agents
Schedule
Schedule H
DailyMed - Xeomin - incobotulinumtoxina injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 10 September 2019]. Available from:
Xeomin 100 units powder for solution for injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2019 [cited 10 September 2019]. Available from:
IncobotulinumtoxinA Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 10 September 2019]. Available from:
[Internet]. Accessdata.fda.gov. 2019 [cited 10 September 2019]. Available from:
Information on this page was last updated on 11 Sep 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.