Imipenem

Description

Imipenem is a beta-lactam antibiotic that is used in combination with cilastatin to treat infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. caused by various types of bacteria.

Side effects

Major & minor side effects for Imipenem

  • Nausea
  • Vomiting
  • Injection site pain
  • Rash
  • Dizziness
  • Sleepiness
  • Seizures

Uses of Imipenem

What is it prescribed for?

  • Lower Respiratory Tract Infection
  • Urinary Tract Infection
  • Intra-abdominal Infection
  • Bacterial Septicemia
  • Bone and Joint infections
  • Endocarditis
  • Skin and Skin Structure Infection
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to imipenem, other carbapenem derivatives, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Seizures

This medicine should be used with caution due to the increased risk of seizures. This risk is especially high in patients with a history of seizures or other central nervous system disorders. Cloe monitoring of these patients for any change in mood or behavior is recommended. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Drug-Resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Clostridium difficile-associated Diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinic or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinic setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Valganciclovir

Sodium Valproate

Cyclosporine

Disease interactions

Central nervous system disorders

This medicine should be used with extreme caution in patients with a history of central nervous system disorders due to the increased risk of severe adverse effects. Report any symptoms such as excessive sleepiness, trembling, depression, hallucinations, confusion, etc. to the doctor immediately. Close monitoring of the patient for any changes in behavior or mood is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Kidney Disease

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine is a broad-spectrum antibiotic that works by interfering with bacterial cell wall synthesis; this eventually leads to the death of bacteria.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Carbapenems

Schedule

Schedule H

Imipenem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 11 April 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/imipenem#section=Top

[Internet]. Accessdata.fda.gov. 2018 [cited 11 April 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf

Imipenem and Cilastatin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 11 April 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a686013.html

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Information on this page was last updated on 30 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.