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Imicrit I.V 250 mg Injection
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Imicrit I.V 250 mg Injection

Manufactured byCIPLA LTD
ContainsImipenem (250 mg) + Cilastatin (250 mg)
Description
Imicrit I.V 250 mg Injection is a combination medicine used to treat infections of the lower respiratory tract, urinary tract, bone and joints, blood, intraabdominal infections, skin and soft tissue infections, etc. caused by various types of bacteria. This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Imicrit I.V 250 mg Injection

  • Nausea
  • Vomiting
  • Rash
  • Hives
  • Itching of skin
  • Injection site pain
  • Dizziness
  • Confusion
  • Increased sweating
  • Unusual tiredness or weakness
  • Diarrhea
  • Stomach cramps

Uses of Imicrit I.V 250 mg Injection

What is it prescribed for?

  • Lower Respiratory Tract Infection
  • Urinary Tract Infection
  • Intra-abdominal Infection
  • Bacterial Septicemia
  • Bone and Joint infections
  • Endocarditis
  • Skin and Skin Structure Infection
  • Gynecological infections
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.

Allergy

This medicine is not recommended for use in patients with a known allergy to imipenem, other carbapenem derivatives, cilastatin, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings

Seizures

This medicine should be used with caution due to the increased risk of seizures. This risk is especially higher in patients with a history of seizures or other central nervous system disorders. Close monitoring of these patients for any change in mood or behavior is recommended. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Drug-Resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Clostridium difficile-associated diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Kidney function impairment

This medicine should be used with extreme caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified health care professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Cholera Vaccine

Valganciclovir

Sodium Valproate

Ethinyl Estradiol

Cyclosporine

Disease interactions

Central nervous system disorders

This medicine should be used with extreme caution in patients with a history of central nervous system disorders due to the increased risk of severe adverse effects. Report any symptoms such as excessive sleepiness, trembling, depression, hallucinations, confusion, etc. to the doctor immediately. Close monitoring of the patient for any changes in behavior or mood is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Kidney Disease

This medicine should be used with extreme caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
This medicine should be administered by a qualified health care professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor promptly.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Imipenem works by interfering with bacterial cell wall synthesis; this eventually leads to the death of bacteria. Cilastatin prevents the breakdown of imipenem in the kidneys and thus increases its effectiveness.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Carbapenems, Dehydropeptidase inhibitor

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 8 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 8 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050587s065,050630s028lbl.pdf

[Internet]. Mhra.gov.uk. 2018 [cited 8 August 2018]. Available from:

http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con140831.pdf

[Internet]. CiplaMed. 2018 [cited 8 August 2018]. Available from:

https://ciplamed.com/content/imicrit-iv-injection
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Information on this page was last updated on 3 Sep 2018

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